Modeling neoplastic disease with spheroids and organoids
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …
components contribute to the development, progression, and metastasization of disease …
How to hit mesenchymal stromal cells and make the tumor microenvironment immunostimulant rather than immunosuppressive
Experimental evidence indicates that mesenchymal stromal cells (MSCs) may regulate
tumor microenvironment (TME). It is conceivable that the interaction with MSC can influence …
tumor microenvironment (TME). It is conceivable that the interaction with MSC can influence …
Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety
A Chramiec, D Teles, K Yeager, A Marturano-Kruik… - Lab on a Chip, 2020 - pubs.rsc.org
Traditional drug screening models are often unable to faithfully recapitulate human
physiology in health and disease, motivating the development of microfluidic organs-on-a …
physiology in health and disease, motivating the development of microfluidic organs-on-a …
Tumor-associated macrophages induce inflammation and drug resistance in a mechanically tunable engineered model of osteosarcoma
The tumor microenvironment is a complex and dynamic ecosystem composed of various
physical cues and biochemical signals that facilitate cancer progression, and tumor …
physical cues and biochemical signals that facilitate cancer progression, and tumor …
Drug resistance in human cancers—Mechanisms and implications
S Vijayakumar, R Dhakshanamoorthy, A Baskaran… - Life Sciences, 2024 - Elsevier
Cancers have complex etiology and pose a significant impact from the health care
perspective apart from the socio-economic implications. The enormity of challenge posed by …
perspective apart from the socio-economic implications. The enormity of challenge posed by …
New advances in the study of bone tumors: a lesson from the 3D environment
Bone primary tumors, such as osteosarcoma, are highly aggressive pediatric tumors that in
30% of the cases develop lung metastasis and are characterized by poor prognosis. Bone is …
30% of the cases develop lung metastasis and are characterized by poor prognosis. Bone is …
Biomechanical studies on biomaterial degradation and co-cultured cells: mechanisms, potential applications, challenges and prospects
Biomechanics contains a wide variety of research fields related to biology and mechanics.
Actually, to better study or develop a tissue-engineered system, it is now widely recognized …
Actually, to better study or develop a tissue-engineered system, it is now widely recognized …
Tissue-engineered 3D models for elucidating primary and metastatic bone cancer progression
Malignant bone tumors are aggressive neoplasms which arise from bone tissue or as a
result of metastasis. The most prevalent types of cancer, such as breast, prostate, and lung …
result of metastasis. The most prevalent types of cancer, such as breast, prostate, and lung …
Biomechanical forces in tissue engineered tumor models
LK Chim, AG Mikos - Current opinion in biomedical engineering, 2018 - Elsevier
Solid tumors are complex three-dimensional (3D) networks of cancer and stromal cells
within a dynamic extracellular matrix. Monolayer cultures fail to recapitulate the native …
within a dynamic extracellular matrix. Monolayer cultures fail to recapitulate the native …
Effects of shear stress gradients on ewing sarcoma cells using 3D printed scaffolds and flow perfusion
JE Trachtenberg, M Santoro, C Williams III… - ACS Biomaterials …, 2018 - ACS Publications
In this work, we combined three-dimensional (3D) scaffolds with flow perfusion bioreactors
to evaluate the gradient effects of scaffold architecture and mechanical stimulation …
to evaluate the gradient effects of scaffold architecture and mechanical stimulation …