The chaotropic effect as an assembly motif in chemistry
Following up on scattered reports on interactions of conventional chaotropic ions (for
example, I−, SCN−, ClO4−) with macrocyclic host molecules, biomolecules, and …
example, I−, SCN−, ClO4−) with macrocyclic host molecules, biomolecules, and …
Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
Weakly hydrated anions bind to polymers but not monomers in aqueous solutions
Weakly hydrated anions help to solubilize hydrophobic macromolecules in aqueous
solutions, but small molecules comprising the same chemical constituents precipitate out …
solutions, but small molecules comprising the same chemical constituents precipitate out …
Water structure recovery in chaotropic anion recognition: high‐affinity binding of dodecaborate clusters to γ‐cyclodextrin
KI Assaf, MS Ural, F Pan, T Georgiev… - Angewandte Chemie …, 2015 - Wiley Online Library
Dodecaborate anions of the type B12X122− and B12X11Y2−(X= H, Cl, Br, I and Y= OH, SH,
NH3+, NR3+) form strong (Ka up to 106 L mol− 1, for B12Br122−) inclusion complexes with …
NH3+, NR3+) form strong (Ka up to 106 L mol− 1, for B12Br122−) inclusion complexes with …
Collaborative routes to clarifying the murky waters of aqueous supramolecular chemistry
On planet Earth, water is everywhere: the majority of the surface is covered with it; it is a key
component of all life; its vapour and droplets fill the lower atmosphere; and even rocks …
component of all life; its vapour and droplets fill the lower atmosphere; and even rocks …
The molecular origin of enthalpy/entropy compensation in biomolecular recognition
Biomolecular recognition can be stubborn; changes in the structures of associating
molecules, or the environments in which they associate, often yield compensating changes …
molecules, or the environments in which they associate, often yield compensating changes …
Hofmeister effect-enhanced gelatin/oxidized dextran hydrogels with improved mechanical properties and biocompatibility for wound healing
B Zhao, Y Zhang, D Li, X Mo, J Pan - Acta Biomaterialia, 2022 - Elsevier
Compared with other types of hydrogels, natural derived hydrogels possess intrinsic
advantages of degradability and biocompatibility. However, due to the low mechanical …
advantages of degradability and biocompatibility. However, due to the low mechanical …
[HTML][HTML] Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids
Ions are important to modulate protein properties, including solubility and stability, through
specific ion effects. Ionic liquids (ILs) are designer salts with versatile ion combinations with …
specific ion effects. Ionic liquids (ILs) are designer salts with versatile ion combinations with …
Modular fabrication of intelligent material-tissue interfaces for bioinspired and biomimetic devices
One of the goals of biomaterials science is to reverse engineer aspects of human and non-
human physiology. Similar to the body's regulatory mechanisms, such devices must …
human physiology. Similar to the body's regulatory mechanisms, such devices must …
The roles of water in the protein matrix: a largely untapped resource for drug discovery
F Spyrakis, MH Ahmed, AS Bayden… - Journal of medicinal …, 2017 - ACS Publications
The value of thoroughly understanding the thermodynamics specific to a drug
discovery/design study is well known. Over the past decade, the crucial roles of water …
discovery/design study is well known. Over the past decade, the crucial roles of water …