Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

L Ferrucci, E Fabbri - Nature Reviews Cardiology, 2018 - nature.com
Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Peripheral markers of depression

A Nobis, D Zalewski, N Waszkiewicz - Journal of clinical medicine, 2020 - mdpi.com
Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high
medical and socioeconomic burden. There is a growing interest in the biological …

Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity

F Calabrese, AC Rossetti, G Racagni… - Frontiers in cellular …, 2014 - frontiersin.org
Cytokines are key regulatory mediators involved in the host response to immunological
challenges, but also play a critical role in the communication between the immune and the …

The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery

J Dahl, H Ormstad, HCD Aass, UF Malt… - …, 2014 - Elsevier
Background Cytokines are implicated in the pathophysiology of major depressive disorder
(MDD). However, the pattern of alterations in cytokine levels is still unclear. The current …

[HTML][HTML] Integrating Interleukin-6 into depression diagnosis and treatment

GE Hodes, C Ménard, SJ Russo - Neurobiology of stress, 2016 - Elsevier
There is growing evidence of a relationship between inflammation and psychiatric illness. In
particular, the cytokine Interleukin-6 (IL-6) has been linked to stress-related disorders such …

Integrating the monoamine, neurotrophin and cytokine hypotheses of depression—a central role for the serotonin transporter?

J Haase, E Brown - Pharmacology & therapeutics, 2015 - Elsevier
Monoamine, in particular serotonergic neurotransmission has long been recognized as an
important factor in the aetiology of depression. The serotonin transporter (SERT) is the …

Macrophages in tumor: An inflammatory perspective

KK Goswami, A Bose, R Baral - Clinical Immunology, 2021 - Elsevier
Inflammation is a part of carefully co-ordinated healing immune exercise to eliminate
injurious stimuli. However, in substantial number of cancer types, it contributes in shaping up …

Making room for oxytocin in understanding depression

RJ McQuaid, OA McInnis, A Abizaid… - … & Biobehavioral Reviews, 2014 - Elsevier
Depression is accompanied by an array of neurobiological variations, including altered HPA
axis activity, monoamine, growth factor and inflammatory immune functioning. In addition, a …

[PDF][PDF] Major depressive disorder: pathophysiology and clinical management

N Fekadu, W Shibeshi, E Engidawork - J Depress Anxiety, 2017 - researchgate.net
Depression is a chronic mental disorder that causes changes in mood, thoughts, behavior
and physical health. It'sa common but serious disease that can take away a person's ability …

Altered serum adiponectin and interleukin-8 levels are associated in the pathophysiology of major depressive disorder: A case-control study

S Islam, T Islam, Z Nahar, M Shahriar, SMA Islam… - PLoS …, 2022 - journals.plos.org
Background Major depressive disorder (MDD) is a complex mental health condition that
results in several obstacles including disabilities, loss of productivity, and economic burdens …