Neuroblastoma is the most common extracranial solid tumor of children. Neuroblastoma
tumors derive from the neural crest and synthesize neurotransmitters including the …

Protein palmitoylation refers to the posttranslational addition of a 16 carbon fatty acid to the
side chain of cysteine, forming a thioester linkage. This acyl modification is readily …

Innate immune responses are mediated by the activation of various signaling processes.
Here, we describe our current knowledge on Janus kinase (JAK)/signal transducers and …

Abstract Members of the Aurora/Ipl1p family of mitotically regulated serine/threonine kinases
are emerging as key regulators of chromosome segregation and cytokinesis. Proper …

Signalling pathways mediating the transduction of information between cells are essential
for development, cellular differentiation and homeostasis. Their dysregulation is also …

The neurotransmitter GABA activates heteropentameric GABAA receptors, which are
composed mostly of α, β, and γ2 subunits. Regulated membrane trafficking and subcellular …

The JAK/STAT pathway was originally identified in mammals. Studies of this pathway in the
mouse have revealed that JAK/STAT signaling plays a central role during hematopoeisis …

DHHC protein acyltransferases (PATs) catalyze the palmitoylation of eukaryotic proteins
through an enzymatic mechanism that remains largely unexplored. In this study we have …

Plasma membrane localization of Ras requires posttranslational addition of farnesyl and
palmitoyl lipid moieties to a C-terminal C aaX motif (C is cysteine, a is any aliphatic residue …

The JAK/STAT signal transduction pathway has been conserved throughout evolution such
that true structural and functional homologues of components originally identified in …