Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

TPC Dorlo, M Balasegaram, JH Beijnen… - Journal of …, 2012 - academic.oup.com
Miltefosine is an alkylphosphocholine drug with demonstrated activity against various
parasite species and cancer cells as well as some pathogenic bacteria and fungi. For 10 …

Drug resistance in leishmaniasis: Newer developments

S Mohapatra - Tropical parasitology, 2014 - journals.lww.com
Leishmaniasis is a vector borne protozoan disease and it remains a major public health
problem world-wide. Lack of an effective vaccine and vector control program makes the …

Miltefosine for visceral and cutaneous leishmaniasis: drug characteristics and evidence-based treatment recommendations

B Monge-Maillo, R López-Vélez - Clinical Infectious Diseases, 2015 - academic.oup.com
Miltefosine is the only recognized oral agent with potential to treat leishmaniasis. Miltefosine
had demonstrated very good cure rates for visceral leishmaniasis (VL) in India, Nepal, and …

Immunotherapy and targeted therapies in treatment of visceral leishmaniasis: current status and future prospects

OP Singh, S Sundar - Frontiers in immunology, 2014 - frontiersin.org
Visceral leishmaniasis (VL) is a vector-borne chronic infectious disease caused by the
protozoan parasite Leishmania donovani or Leishmania infantum. VL is a serious public …

Drug susceptibility in Leishmania isolates following miltefosine treatment in cases of visceral leishmaniasis and post kala-azar dermal leishmaniasis

V Bhandari, A Kulshrestha, DK Deep… - PLoS neglected …, 2012 - journals.plos.org
Background With widespread resistance to antimonials in Visceral Leishmaniasis (VL) in the
Indian subcontinent, Miltefosine (MIL) has been introduced as the first line therapy …

Post‐kala‐azar dermal leishmaniasis–an overview

S Ganguly, NK Das, JN Barbhuiya… - International journal of …, 2010 - Wiley Online Library
Post‐kala‐azar dermal leishmaniasis (PKDL) is a dermal sequela of visceral leishmaniasis
(VL), reported mainly from two regions–Sudan in eastern Africa and the Indian subcontinent …

Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo

K Seifert, FJ Pérez-Victoria, M Stettler… - International journal of …, 2007 - Elsevier
Miltefosine (hexadecylphosphocholine) is the first oral antileishmanial drug. In this study, we
addressed the question whether miltefosine-resistant Leishmania donovani promastigotes …

Comparative stability, toxicity and anti-leishmanial activity of triphenyl antimony (v) and bismuth (v) α-hydroxy carboxylato complexes

RN Duffin, VL Blair, L Kedzierski, PC Andrews - Dalton Transactions, 2018 - pubs.rsc.org
A series of triphenyl Sb (V) and Bi (V) α-hydroxy carboxylato complexes of the general
formula [MPh3 (O2CROH) 2] and [MPh3 (O2CRO)] have been successfully synthesised and …

Post kala-azar dermal leishmaniasis in the Indian sub-continent: challenges and strategies for elimination

A Kumar, VK Singh, R Tiwari, P Madhukar… - Frontiers in …, 2023 - frontiersin.org
Visceral leishmaniasis (VL) is a severe and often fatal form of leishmaniasis caused by
Leishmania donovani in the Indian sub-continent. Post Kala-azar Dermal Leishmaniasis …

Safety and effectiveness of miltefosine in post–kala-azar dermal leishmaniasis: an observational study

S Sundar, J Singh, A Dinkar… - Open Forum Infectious …, 2023 - academic.oup.com
Background Post–kala-azar dermal leishmaniasis (PKDL) is a dermal complication of
visceral leishmaniasis. Oral miltefosine (MF) is the first-line treatment for PKDL patients in …