The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer
treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the …

Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely,
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …

Rationale: Cancer immunotherapy combining immune checkpoint blockade (ICB) with
chemotherapeutic drugs has provided significant clinical advances. However, such …

The ferritin nanocage is an endogenous protein that exists in almost all mammals. Its hollow
spherical structure that naturally stores iron ions has been diversely exploited by …

Ferritin has been widely recognized as an ideal drug delivery vehicle owing to its unique
cage-like structure. Coupled with intrinsic targeting ability and excellent biosafety, ferritin …

The physical properties of nanomaterials—such as size, structure, shape, charge,
mechanical strength and hydrophobicity—can directly or indirectly influence immune cell …

Immunogenic cell death (ICD)‐induced immunotherapy holds promise for complete
elimination and long‐term protective immune responses against cancer by combining direct …

Chemoimmunotherapy can synergistically enhance the therapeutic effects and decrease the
side effects by a combined method. However, the effective targeted codelivery of various …

Background Ferritin, a ubiquitously distributed iron storage protein, can specifically target
tumor cells through transferrin receptor 1. Due to its rearrangeable nanocage structure …

Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis showed remarkable
improvements in overall response and patient survival, which changed the treatment …