Acute myeloid leukemia (AML) still represents an unmet clinical need for adult and pediatric
patients. Adoptive cell therapy by chimeric antigen receptor (CAR)-engineered T cells …

Background Among the major challenges in next-generation sequencing experiments are
exploratory data analysis, interpreting trends, identifying potential targets/candidates, and …

The administration of combinations of drugs is a method widely used in the treatment of
different pathologies as it can lead to an increase in the therapeutic effect and a reduction in …

NPM1 is the most frequently mutated gene in adults with acute myeloid leukemia (AML). The
interaction between mutant NPM1 (NPM1c) and exportin-1 (XPO1) causes aberrant …

The methylation status of histones plays a crucial role in many cellular processes, including
follicular and oocyte development. Lysine-specific demethylase 2a (KDM2a) has been …

Introduction: Cervical cancer (CC) is the fourth most common cancer type and a leading
cause of cancer-related deaths in women worldwide. Its underlying molecular mechanisms …

Lysyl oxidase-like 3 (LOXL3), belonging to the lysyl oxidase family, is responsible for the
crosslinking in collagen or elastin. The cellular localization of LOXL3 is in the extracellular …

This study aims to identify RNA biomarkers distinguishing neuromyelitis optica (NMO) from
relapsing-remitting multiple sclerosis (RRMS) and explore potential therapeutic applications …

RNA-seq is a sequencing technique that uses next-generation sequencing (NGS) to explore
and study the entire transcriptome of a biological sample. NGS-based analyses are mostly …

The analysis of genomics data involves multistep complex tasks that require intervention by
the operator for execution, in addition to consume a substantial amount of computational …