Immunity to Cryptosporidium: insights into principles of enteric responses to infection
Cryptosporidium parasites replicate within intestinal epithelial cells and are an important
cause of diarrhoeal disease in young children and in patients with primary and acquired …
cause of diarrhoeal disease in young children and in patients with primary and acquired …
Ghost authors revealed: The structure and function of human N6‐methyladenosine RNA methyltransferases
K Breger, CN Kunkler, NJ O'Leary… - Wiley …, 2024 - Wiley Online Library
Despite the discovery of modified nucleic acids nearly 75 years ago, their biological
functions are still being elucidated. N 6‐methyladenosine (m6A) is the most abundant …
functions are still being elucidated. N 6‐methyladenosine (m6A) is the most abundant …
m6A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration
Neutrophil migration into the site of infection is necessary for antibacterial innate defense,
whereas impaired neutrophil migration may result in excessive inflammation and even …
whereas impaired neutrophil migration may result in excessive inflammation and even …
Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses
Cryptosporidium infects gastrointestinal epithelium and is a leading cause of infectious
diarrhea and diarrheal-related death in children worldwide. There are no vaccines and no …
diarrhea and diarrheal-related death in children worldwide. There are no vaccines and no …
LOX-1 acts as an N6-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase
The role of N6-methyladenosine (m6A) modification of host mRNA during bacterial infection
is unclear. Here, we show that Helicobacter pylori infection upregulates host m6A …
is unclear. Here, we show that Helicobacter pylori infection upregulates host m6A …
Early immune and host cell responses to Cryptosporidium infection
JR Mead - Frontiers in parasitology, 2023 - frontiersin.org
Cryptosporidium spp. are opportunistic protozoan parasites that infect epithelial cells of the
small intestine and cause diarrheal illness in both immunocompetent and immunodeficient …
small intestine and cause diarrheal illness in both immunocompetent and immunodeficient …
Nurturing gut health: role of m6A RNA methylation in upholding the intestinal barrier
S Wang, Y Yang, X Jiang, X Zheng, Q Wei, W Dai… - Cell Death …, 2024 - nature.com
The intestinal lumen acts as a critical interface connecting the external environment with the
body's internal state. It's essential to prevent the passage of harmful antigens and bacteria …
body's internal state. It's essential to prevent the passage of harmful antigens and bacteria …
Mutligenerational chronic exposure to near future ocean acidification in European sea bass (Dicentrarchus labrax): Insights into the regulation of the transcriptome in a …
In this study, we examined the effect of near future ocean acidification (OA) on the
transcriptome of a sensory organ in contact with surrounding water, the tongue in adult …
transcriptome of a sensory organ in contact with surrounding water, the tongue in adult …
Cryptosporidium Genomics — Current Understanding, Advances, and Applications
Abstract Purpose of Review Here we highlight the significant contribution that genomics-
based approaches have had on the field of Cryptosp oridium research and the insights …
based approaches have had on the field of Cryptosp oridium research and the insights …
[HTML][HTML] Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions
Y Lu, X Zhang, Z Guan, R Ji, F Peng, C Zhao, W Gao… - Parasite, 2025 - pmc.ncbi.nlm.nih.gov
Cryptosporidiosis, caused by a Cryptosporidium infection, is a serious gastrointestinal
disease commonly leading to diarrhea in humans. This disease poses a particular threat to …
disease commonly leading to diarrhea in humans. This disease poses a particular threat to …