Regulation of DNA fragmentation: the role of caspases and phosphorylation
I Kitazumi, M Tsukahara - The FEBS journal, 2011 - Wiley Online Library
DNA fragmentation is a hallmark of apoptosis that is induced by apoptotic stimuli in various
cell types. Apoptotic signal pathways, which eventually cause DNA fragmentation, are …
cell types. Apoptotic signal pathways, which eventually cause DNA fragmentation, are …
[PDF][PDF] NAD+ and NADH in cellular functions and cell death
W Ying - Front Biosci, 2006 - article.imrpress.com
Introduction 3. NAD+ and NADH metabolism in cells 3.1. General information about NAD+
and NADH 3.2. NAD+ and NADH synthesis 3.3. NAD+ and NADH catabolism 4. NAD+ and …
and NADH 3.2. NAD+ and NADH synthesis 3.3. NAD+ and NADH catabolism 4. NAD+ and …
Reprogramming cellular events by poly (ADP-ribose)-binding proteins
J Krietsch, M Rouleau, É Pic, C Ethier… - Molecular aspects of …, 2013 - Elsevier
Poly (ADP-ribosyl) ation is a posttranslational modification catalyzed by the poly (ADP-
ribose) polymerases (PARPs). These enzymes covalently modify glutamic, aspartic and …
ribose) polymerases (PARPs). These enzymes covalently modify glutamic, aspartic and …
PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks
J Krietsch, MC Caron, JP Gagne, C Ethier… - Nucleic acids …, 2012 - academic.oup.com
After the generation of DNA double-strand breaks (DSBs), poly (ADP-ribose) polymerase-1
(PARP-1) is one of the first proteins to be recruited and activated through its binding to the …
(PARP-1) is one of the first proteins to be recruited and activated through its binding to the …
Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression
YG Jang, EB Ko, KC Choi - The Journal of nutritional biochemistry, 2020 - Elsevier
Gallic acid (GA) is known to possess diverse biological activities, including anticancer.
Histone deacetylase (HDACs) are controlled by tumor suppressor gene transcription and …
Histone deacetylase (HDACs) are controlled by tumor suppressor gene transcription and …
A novel selenium analog of HDACi-based twin drug induces apoptosis and cell cycle arrest via CDC25A to improve prostate cancer therapy
Z Shi, M Liu, X Zhang, J Wang, J Zhang, Z Peng… - …, 2024 - pmc.ncbi.nlm.nih.gov
Cancer therapy has moved from single agents to more mechanism-based targeted
approaches. In recent years, the combination of HDAC inhibitors and other anticancer …
approaches. In recent years, the combination of HDAC inhibitors and other anticancer …
The Rho kinase inhibitor fasudil attenuates Aβ1–42-induced apoptosis via the ASK1/JNK signal pathway in primary cultures of hippocampal neurons
Y Gao, Y Yan, Q Fang, N Zhang, G Kumar… - Metabolic brain …, 2019 - Springer
Abstract Alzheimer's disease (AD), a chronic, progressive, neurodegenerative disorder, is
the most common type of dementia. Beta amyloid (Aβ) peptide aggregation and …
the most common type of dementia. Beta amyloid (Aβ) peptide aggregation and …
[HTML][HTML] New therapeutic activity of metabolic enhancer piracetam in treatment of neurodegenerative disease: Participation of caspase independent death factors …
Piracetam, a nootropic drug that has been clinically used for decades but remains enigmatic
due to no distinct understanding of its mechanism of action. The present study aimed to …
due to no distinct understanding of its mechanism of action. The present study aimed to …
Scutellarin protects mouse ovarian granulosa cells from injury induced by the toxin zearalenone
Zearalenone (ZEA), present in animal grain feed is produced by Fusarium fungi and this
toxin targets ovarian granulosa cells (GCs) to cause reproductive disorders in female …
toxin targets ovarian granulosa cells (GCs) to cause reproductive disorders in female …
Contemporary views on the pathogenesis of trauma to the spinal cord and peripheral nerve trunks
AE Shul'ga, IA Norkin, VG Ninel'… - Neuroscience and …, 2015 - Springer
The pathogenesis of traumatic spinal cord disease involves two mechanisms causing injury
to its neuronal apparatus: primary (necrosis) and secondary (apoptosis). This study …
to its neuronal apparatus: primary (necrosis) and secondary (apoptosis). This study …