The centrosome acts as the major microtubule-organizing center (MTOC) for cytoskeleton
maintenance in interphase and mitotic spindle assembly in vertebrate cells. It duplicates …

Centrioles are among the largest protein-based structures found in most cell types,
measuring approximately 250 nm in diameter and approximately 500 nm long in vertebrate …

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

INTRODUCTION Mammalian embryos frequently develop abnormally, resulting in
miscarriages and genetic disorders such as Down syndrome. The major cause for aberrant …

Centrosomes and primary cilia are usually considered as distinct organelles, although both
are assembled with the same evolutionary conserved, microtubule-based templates, the …

The centrosome linker joins the two interphase centrosomes of a cell into one microtubule
organizing center. Despite increasing knowledge on linker components, linker diversity in …

The centrosome is the main microtubule (MT)-organizing centre of animal cells. It consists of
two centrioles and a multi-layered proteinaceous structure that surrounds the centrioles, the …

Mitosis requires extensive rearrangement of cellular architecture and of subcellular
structures so that replicated chromosomes can bind correctly to spindle microtubules and …

Genetic studies in yeast and Drosophila led to identification of cyclin-dependent kinases
(CDKs), Polo-like kinases (PLKs) and Aurora kinases as essential regulators of mitosis …

The primary cilium is elongated from the mother centriole and has diverse signaling roles
during development and disease. The CP110-CEP97 complex functions as a negative …