Hemoglobinopathies, including β-thalassemia and sickle cell disease (SCD), are common
genetic blood disorders. Endocrine disorders are frequent manifestations of organ damage …

Beta thalassemia is the most common genetic blood disorder, characterized by reduced
production or complete absence of beta-globin chains. The combination of systematic red …

Purpose Transfusion-dependent beta-thalassemia (TDT) patients suffer from various
endocrinopathies. The main contributing factor associated with these complications is iron …

Thalassemia syndromes are complex systemic disorders. Clinical complications are related
to the underlying pathophysiological mechanisms, namely ineffective erythropoiesis, chronic …

As a cause of chronic blood transfusions, iron overload is an important issue in β-
thalassemia (β-thal) patients that leads to multiple organ dysfunctions. This is an updated …

Background In young children, β-thalassemia major (β-TM) is associated with potentially
severe clinical characteristics, including poor growth, feeding difficulties …

Background: Endocrinopathies are now amongst the common complications of thalassemia
but determining the exact prevalence is difficult because of differences in age of first …

BACKGROUND: Beta-thalassemia, a hereditary blood disease transmitted through families,
has become increasingly relevant with rising life expectancies, leading to bone disease …

Hypoparathyroidism is characterized by insufficient parathyroid hormone (PTH) release from
the parathyroid glands to maintain serum calcium level within normal limits and …

Objectives: To investigate the prevalence and significance of different endocrinopathies in
children and adolescents with transfusion-dependent thalassemia and sickle-cell anemia …