Increases in neuronal activity in response to tissue injury lead to changes in gene
expression and prolonged changes in the nervous system. These functional changes …

Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain;
however, the roles of GABA in antimicrobial host defenses are largely unknown. Here we …

mu opiate receptors recognize morphine with high affinity. A 2.1-kb rat brain cDNA whose
predicted translation product displays 63% identity with recently described delta and kappa …

New, more effective pharmacologic treatments for epilepsy are needed, as a substantial
portion of patients (> 30%) are refractory to currently available anti-epileptic drugs …

Binding of the neurosteroid dehydroepiandrosterone sulfate (DHEAS) to rat brain
synaptosomal membranes was studied in vitro, and the interaction of DHEAS with the GABA …

Peptides released in the spinal cord from the central terminals of nociceptors contribute to
the persistent hyperalgesia that defines the clinical experience of chronic pain. Using …

In this paper, we describe the synthesis of a series of novel substituted 4-aryl-6, 7-
methylenedioxyphthalazin-1 (2 H)-ones. The anticonvulsant activity of these compounds …

Publisher Summary This chapter discusses evolutionary aspects of injury-related behavior,
and examines behavioral, physiological, and molecular aspects of potentially adaptive …

Although the opioids are the principal treatment options for moderate to severe pain, their
use is also associated with the development of tolerance, defined as the progressive need …

In nerve cells, a specialized protein synthetic machinery is thought to operate in local
compartments of dendrites, in particular beneath synaptic junctions, and thereby to facilitate …