The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are
among the most important and abundant players of the tumor microenvironment. CAFs as …

Interactions between stromal fibroblasts and cancer cells generate signals for cancer
progression, therapy resistance, and inflammatory responses. Although endogenous RNAs …

The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer
progression remain to be fully understood. While altered glucose metabolism in CAFs could …

There is much cellular heterogeneity in the tumor microenvironment. The tumor epithelia
and stromal cells co-evolve, and this reciprocal relationship dictates almost every step of …

Tumor-or cancer-associated fibroblasts (CAFs) are one of the most abundant stromal cell
types in different carcinomas and comprise a heterogeneous cell population. Classically …

Tumor cells exist in close proximity with non-malignant cells. Extensive and multilayered
crosstalk between tumor cells and stromal cells tailors the tumor microenvironment (TME) to …

The extracellular matrix (ECM) is a major component of tumors and a significant contributor
to cancer progression. In this study, we use proteomics to investigate the ECM of human …

The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but
as an important modulator and even a driver of tumorigenicity. Within the tumor stromal …

Pancreatic tumors are known to harbor an abundant and highly desmoplastic stroma.
Among the various cell types that reside within tumor stroma, cancer-associated fibroblasts …