Puzzles, challenges, and information reservoir of SARS-CoV-2 quasispecies
E Domingo, B Martínez-González… - Journal of …, 2023 - Am Soc Microbiol
Upon the emergence of SARS-CoV-2 in the human population, it was conjectured that for
this coronavirus the dynamic intra-host heterogeneity typical of RNA viruses would be toned …
this coronavirus the dynamic intra-host heterogeneity typical of RNA viruses would be toned …
Next-generation sequencing for confronting virus pandemics
Virus pandemics have happened, are happening and will happen again. In recent decades,
the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of …
the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of …
Genetic drift, purifying selection and vector genotype shape dengue virus intra-host genetic diversity in mosquitoes
S Lequime, A Fontaine, M Ar Gouilh… - PLoS …, 2016 - journals.plos.org
Due to their error-prone replication, RNA viruses typically exist as a diverse population of
closely related genomes, which is considered critical for their fitness and adaptive potential …
closely related genomes, which is considered critical for their fitness and adaptive potential …
Deep sequencing: becoming a critical tool in clinical virology
ME Quiñones-Mateu, S Avila, G Reyes-Teran… - Journal of clinical …, 2014 - Elsevier
Population (Sanger) sequencing has been the standard method in basic and clinical DNA
sequencing for almost 40 years; however, next-generation (deep) sequencing …
sequencing for almost 40 years; however, next-generation (deep) sequencing …
[HTML][HTML] Viral quasispecies complexity measures
Mutant spectrum dynamics (changes in the related mutants that compose viral populations)
has a decisive impact on virus behavior. The several platforms of next generation …
has a decisive impact on virus behavior. The several platforms of next generation …
Within-host viral diversity: a window into viral evolution
AS Lauring - Annual Review of Virology, 2020 - annualreviews.org
The evolutionary dynamics of a virus can differ within hosts and across populations. Studies
of within-host evolution provide an important link between experimental studies of virus …
of within-host evolution provide an important link between experimental studies of virus …
Extreme infectious titer variability in individual Aedes aegypti mosquitoes infected with Sindbis virus is associated with both differences in virus population structure …
Variability in how individuals respond to pathogens is a hallmark of infectious disease, yet
the basis for individual variation in host response is often poorly understood. The titer of …
the basis for individual variation in host response is often poorly understood. The titer of …
High-resolution hepatitis C virus subtyping using NS5B deep sequencing and phylogeny, an alternative to current methods
Hepatitis C virus (HCV) is classified into seven major genotypes and 67 subtypes. Recent
studies have shown that in HCV genotype 1-infected patients, response rates to regimens …
studies have shown that in HCV genotype 1-infected patients, response rates to regimens …
Lethal mutagenesis of hepatitis C virus induced by favipiravir
Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an
excess of mutations acquired during replication in the presence of a mutagen. Here we …
excess of mutations acquired during replication in the presence of a mutagen. Here we …
Metagenomic analysis of primary colorectal carcinomas and their metastases identifies potential microbial risk factors
The paucity of microbiome studies at intestinal tissues has contributed to a yet limited
understanding of potential viral and bacterial cofactors of colorectal cancer (CRC) …
understanding of potential viral and bacterial cofactors of colorectal cancer (CRC) …