A wide range of neurodegenerative diseases (NDs), including Alzheimer's disease,
Parkinson's disease, Huntington's disease, and prion diseases, share common mechanisms …

The blood–brain barrier (BBB) forms a protective barrier around the brain, with the important
function of maintaining brain homeostasis. Pathways thought to initiate BBB dysfunction …

Individuals with hemizygous germline fumarate hydratase (FH) mutations are predisposed to
renal cancer. These tumors predominantly exhibit functional inactivation of the remaining …

Both reversible and irreversible inhibition of mitochondrial respiration have been reported
following the generation of nitric oxide (NO) by cells. Using J774 cells, we have studied the …

An impairment of energy metabolism may underlie slow excitotoxic neuronal death in
neurodegenerative diseases. We therefore examined the effects of intrastriatal, subacute …

3-Nitropropionic acid (3-NPA)—a suicide inhibitor of succinate dehydrogenase—is a widely
distributed plant and fungal neurotoxin known to induce damage to basal ganglia …

Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the
gene encoding Huntingtin. The mechanisms underlying the preferential degeneration of the …

Reactive oxygen species (ROS) are generated as the result of a number of physiological
and pathological processes. Once formed ROS can promote multiple forms of oxidative …

Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …

The prevalence of allergies and asthma among the world's population has been steadily
increasing due to environmental factors. It has been described that exposure to ozone …