The role of macrophages in HIV-1 persistence and pathogenesis
Z Kruize, NA Kootstra - Frontiers in microbiology, 2019 - frontiersin.org
Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
Macrophages and their relevance in Human Immunodeficiency Virus Type I infection
H Koppensteiner, R Brack-Werner, M Schindler - Retrovirology, 2012 - Springer
Macrophages are important target cells for the Human Immunodeficiency Virus Type I (HIV-
1) in vivo. Several studies have assessed the molecular biology of the virus in this cell type …
1) in vivo. Several studies have assessed the molecular biology of the virus in this cell type …
NEAT1 long noncoding RNA and paraspeckle bodies modulate HIV-1 posttranscriptional expression
Q Zhang, CY Chen, VSRK Yedavalli, KT Jeang - MBio, 2013 - Am Soc Microbiol
Most of the human genome is transcribed into protein-noncoding RNAs (ncRNAs), including
small ncRNAs and long ncRNAs (lncRNAs). Over the past decade, rapidly emerging …
small ncRNAs and long ncRNAs (lncRNAs). Over the past decade, rapidly emerging …
The Paf1 complex: a keystone of nuclear regulation operating at the interface of transcription and chromatin
The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …
regulation of chromatin structure. A host of proteins required for the disassembly …
A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV
M OhAinle, L Helms, J Vermeire, F Roesch, D Humes… - Elife, 2018 - elifesciences.org
Interferon (IFN) inhibits HIV replication by inducing antiviral effectors. To comprehensively
identify IFN-induced HIV restriction factors, we assembled a CRISPR sgRNA library of …
identify IFN-induced HIV restriction factors, we assembled a CRISPR sgRNA library of …
The sound of silence: mechanisms and implications of HUSH complex function
M Seczynska, PJ Lehner - Trends in Genetics, 2023 - cell.com
The vertebrate genome is under constant threat of invasion by genetic parasites. Whether
the host can immediately recognize and respond to invading elements has been unclear …
the host can immediately recognize and respond to invading elements has been unclear …
HIV-2/SIV viral protein X counteracts HUSH repressor complex
G Chougui, S Munir-Matloob, R Matkovic… - Nature …, 2018 - nature.com
To evade host immune defences, human immunodeficiency viruses 1 and 2 (HIV-1 and HIV-
2) have evolved auxiliary proteins that target cell restriction factors. Viral protein X (Vpx) from …
2) have evolved auxiliary proteins that target cell restriction factors. Viral protein X (Vpx) from …
Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex
Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape
eradication by the host immune system and by antiviral drugs. These same factors, however …
eradication by the host immune system and by antiviral drugs. These same factors, however …
Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition
JL Goodier, LE Cheung… - Nucleic acids research, 2013 - academic.oup.com
LINE1s occupy 17% of the human genome and are its only active autonomous mobile DNA.
L1s are also responsible for genomic insertion of processed pseudogenes and> 1 million …
L1s are also responsible for genomic insertion of processed pseudogenes and> 1 million …