Simple Summary O-linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational
modification (PTM) linking nutrient flux through the hexosamine biosynthetic pathway (HBP) …

O-linked β-DN-acetylglucosamine (O-GlcNAc), as a posttranslational modification (PTM), is
a reversible reaction that attaches β-N-GlcNAc to Ser/Thr residues on specific proteins by O …

Ischemic stroke is the second leading cause of death worldwide with limited medications
and neuroinflammation was recognized as a critical player in the progression of stroke, but …

Abstract Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that
catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex …

Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation), a dynamic post-
translational modification (PTM), holds profound implications in controlling various cellular …

Glycoproteins with diverse glycans are essential to human cells, and subtle differences in
glycan structures may result in entirely different functions. One typical example is proteins …

Prevalent dysregulation of epigenetic modifications plays a pivotal role in cancer. Targeting
epigenetic abnormality is a new strategy for cancer therapy. Understanding how …

Cellular identity in multicellular organisms is maintained by characteristic transcriptional
networks, nutrient consumption, energy production and metabolite utilization. Integrating …

Background KDM6A, a histone demethylase, is frequently mutated in bladder cancer (BCa).
However, the role and detailed molecular mechanism of KDM6A involved in bladder cancer …

Simple Summary Nutritional disorders represent major risk factors for colorectal cancer
according to mechanisms of action that are still insufficiently known. The aim of our study …