Migration of epithelial cells is fundamental to multiple developmental processes, epithelial
tissue morphogenesis and maintenance, wound healing and metastasis. While migrating …

Epidermolysis bullosa simplex (EBS) is a group of inherited keratinopathies that, in most
cases, arise due to mutations in keratins and lead to intraepidermal ruptures. The cellular …

A variety of metastatic cancer cells use actin-rich membrane protrusions, known as
invadopodia, for efficient ECM degradation, which involves trafficking of proteases from …

Adaptations can endow species with complex traits that enable them to occupy new niches.
To adapt to the arboreal lifestyle, treefrogs have evolved a suite of complex traits for climbing …

The plakin family of cytolinkers interacts with intermediate filaments (IFs) through plakin
repeat domain (PRD) and linker modules. Recent structure/function studies have …

The Par polarity complex, consisting of Par3, Par6 and atypical protein kinase C (aPKC),
plays a crucial role in the establishment and maintenance of cell polarity. Although activation …

The endoparasitic pathogen, Plasmodium falciparum (Pf), modulates protein-protein
interactions to employ post-translational modifications like SUMOylation to establish …

Background: Cryoablation induces antitumor immune responses. Spatial transcriptomic
landscape technology has been used to determine the micron-level panoramic …

Bidirectional nucleo-cytoplasmic transport, regulating several vital cellular processes, is
mediated by the Nuclear Pore Complex (NPC) comprising the nucleoporin (Nup) proteins …

Background The aim of this paper was to investigate the clinical significance of periplakin
(PPL) expression in ovarian cancer (OV) tissues and to explore the influence and possible …