Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies
Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs)
are tremendous, the design and discovery of new candidates remain a time and cost …
are tremendous, the design and discovery of new candidates remain a time and cost …
Assessing developability early in the discovery process for novel biologics
Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …
Selecting and screening for such attributes early in the drug development process can save …
Predicting antibody developability profiles through early stage discovery screening
M Bailly, C Mieczkowski, V Juan, E Metwally… - MAbs, 2020 - Taylor & Francis
Monoclonal antibodies play an increasingly important role for the development of new drugs
across multiple therapy areas. The term 'developability'encompasses the feasibility of …
across multiple therapy areas. The term 'developability'encompasses the feasibility of …
Trends in industrialization of biotherapeutics: a survey of product characteristics of 89 antibody-based biotherapeutics
There is considerable interest in the pharmaceutical industry toward development of
antibody-based biotherapeutics because they can selectively bind diverse receptors and …
antibody-based biotherapeutics because they can selectively bind diverse receptors and …
Identifying developability risks for clinical progression of antibodies using high-throughput in vitro and in silico approaches
With the growing significance of antibodies as a therapeutic class, identifying developability
risks early during development is of paramount importance. Several high-throughput in vitro …
risks early during development is of paramount importance. Several high-throughput in vitro …
Blueprint for antibody biologics developability
Large-molecule antibody biologics have revolutionized medicine owing to their superior
target specificity, pharmacokinetic and pharmacodynamic properties, safety and toxicity …
target specificity, pharmacokinetic and pharmacodynamic properties, safety and toxicity …
Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development
Effective translation of breakthrough discoveries into innovative products in the clinic
requires proactive mitigation or elimination of several drug development challenges. These …
requires proactive mitigation or elimination of several drug development challenges. These …
Structure, heterogeneity and developability assessment of therapeutic antibodies
Y Xu, D Wang, B Mason, T Rossomando, N Li, D Liu… - MAbs, 2019 - Taylor & Francis
Increasing attention has been paid to developability assessment with the understanding that
thorough evaluation of monoclonal antibody lead candidates at an early stage can avoid …
thorough evaluation of monoclonal antibody lead candidates at an early stage can avoid …
Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics
Machine learning has been recently used to predict therapeutic antibody aggregation rates
and viscosity at high concentrations (150 mg/ml). These works focused on commercially …
and viscosity at high concentrations (150 mg/ml). These works focused on commercially …
A machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties
Identification of favorable biophysical properties for protein therapeutics as part of
developability assessment is a crucial part of the preclinical development process …
developability assessment is a crucial part of the preclinical development process …