Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

BD Semple, K Blomgren, K Gimlin, DM Ferriero… - Progress in …, 2013 - Elsevier
Hypoxic-ischemic and traumatic brain injuries are leading causes of long-term mortality and
disability in infants and children. Although several preclinical models using rodents of …

Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges

LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain

D Ma, P Williamson, A Januszewski… - The Journal of the …, 2007 - pubs.asahq.org
Background Anesthetics, including isoflurane and nitrous oxide, an antagonist of the N-
methyl-D-aspartate subtype of the glutamate receptor, have been demonstrated to induce …

IFATS collection: the conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats

X Wei, Z Du, L Zhao, D Feng, G Wei, Y He, J Tan… - Stem …, 2009 - academic.oup.com
Adipose tissue stroma contains a population of mesenchymal stem cells, which support
repair when administered to damaged tissues, in large part through secreted trophic factors …

Neuroprotective role of lactate in rat neonatal hypoxia-ischemia

H Roumes, U Dumont, S Sanchez… - Journal of Cerebral …, 2021 - journals.sagepub.com
Hypoxic-ischemic (HI) encephalopathy remains a major cause of perinatal mortality and
chronic disability in newborns worldwide (1–6 for 1000 births). The only current clinical …

Neurological reflexes and early motor behavior in rats subjected to neonatal hypoxic–ischemic injury

A Lubics, D Reglődi, A Tamás, P Kiss, M Szalai… - Behavioural brain …, 2005 - Elsevier
Severe perinatal hypoxia–ischemia is an important cause of brain injury in both full-term and
premature newborns, with a high risk of future behavioral and neurological deficits. The most …

Sex differences in behavioral outcome following neonatal hypoxia ischemia: insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic …

AL Smith, M Alexander, TS Rosenkrantz… - Experimental …, 2014 - Elsevier
Hypoxia ischemia (HI; reduced oxygen and/or blood flow to the brain) is one of the most
common injuries among preterm infants and term infants with birth complications. Both …

Cannabidiol administration after hypoxia–ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function

MR Pazos, V Cinquina, A Gómez, R Layunta… - …, 2012 - Elsevier
Cannabidiol (CBD) demonstrated short-term neuroprotective effects in the immature brain
following hypoxia–ischemia (HI). We examined whether CBD neuroprotection is sustained …

Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia–ischemia in rats

A Kumral, N Uysal, K Tugyan, A Sonmez… - Behavioural brain …, 2004 - Elsevier
It is well known that neonatal hypoxic–ischemic brain injury leads to mental retardation and
deficits in cognitive abilities such as learning and memory in human beings. The …

Melatonin protects from the long‐term consequences of a neonatal hypoxic‐ischemic brain injury in rats

S Carloni, S Perrone, G Buonocore… - Journal of pineal …, 2008 - Wiley Online Library
Among the main factors responsible for perinatal brain injury, inflammation, hypoxia‐
ischemia and formation of free radicals (FR) appear to play key roles. Melatonin, an …