The frequent occurrence of transcription and DNA replication in cells results in many
encounters, and thus conflicts, between the transcription and replication machineries. These …

The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Abstract The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1
DNA helicase family, which is conserved from bacteria to humans. Here we show that …

Aberrant DNA replication is a major source of the mutations and chromosome
rearrangements that are associated with pathological disorders. When replication is …

Summary G-quadruplex (G4) DNA structures are extremely stable four-stranded secondary
structures held together by noncanonical GG base pairs. Genome-wide chromatin …

Genomic instability in the form of mutations and chromosome rearrangements is usually
associated with pathological disorders, and yet it is also crucial for evolution. Two types of …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Accurate and complete replication of the genome in every cell division is a prerequisite of
genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely …

Covalent DNA-protein cross-links (DPCs) impede replication fork progression and threaten
genome integrity. Using Xenopus egg extracts, we previously showed that replication fork …

In response to DNA damage and blocks to replication, eukaryotes activate the checkpoint
pathways that prevent genomic instability and cancer by coordinating cell cycle progression …