Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …

Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …

Lipid rafts are dynamic assemblies of proteins and lipids that harbour many receptors and
regulatory molecules and so act as a platform for signal transduction. They float freely within …

Cholesterol is an essential component of mammalian cells. It is the major lipid constituent of
the plasma membrane and is also abundant in most other organelle membranes. In the …

Lipid rafts and caveolae play a pivotal role in organization of signaling by TLR4 and several
other immune receptors. Beyond the simple cataloguing of signaling events …

The plasma membrane has a highly asymmetric distribution of lipids and contains dynamic
nanodomains many of which are liquid entities surrounded by a second, slightly different …

Theoretical studies predict hydrophobic matching between transmembrane domains of
proteins and bilayer lipids to be a physical mechanism by which membranes laterally self …

The organization of eukaryotic membranes into functional domains continues to fascinate
and puzzle cell biologists and biophysicists. The lipid raft hypothesis proposes that collective …

Lipid rafts are nanoscopic compartments of cell membranes that serve a variety of biological
functions. They play a crucial role in viral infections, as enveloped viruses such as severe …

In this study, we asked whether exposure to different physiologically relevant temperatures
(33° C, 37° C, and 39.5° C) could affect subsequent antigen-specific, activation-related …