[HTML][HTML] Identification of regulatory molecular “hot spots” for LH/PLOD collagen glycosyltransferase activity
D Mattoteia, A Chiapparino, M Fumagalli… - International Journal of …, 2023 - mdpi.com
Hydroxylysine glycosylations are post-translational modifications (PTMs) essential for the
maturation and homeostasis of fibrillar and non-fibrillar collagen molecules. The …
maturation and homeostasis of fibrillar and non-fibrillar collagen molecules. The …
Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network
Z Yang, L Zhou, T Si, S Chen, C Liu, KK Ng, Z Wang… - Molecular Cancer, 2023 - Springer
Background Excessive extracellular matrix deposition and increased stiffness are typical
features of solid tumors such as hepatocellular carcinoma (HCC) and pancreatic ductal …
features of solid tumors such as hepatocellular carcinoma (HCC) and pancreatic ductal …
Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects
Thoracic aortic aneurysm (TAA) is a life-threatening vascular disease frequently associated
with underlying genetic causes. An inadequate understanding of human TAA pathogenesis …
with underlying genetic causes. An inadequate understanding of human TAA pathogenesis …
Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness
M Faleeva, S Ahmad, K Theofilatos, S Lynham… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: Vascular calcification and increased extracellular matrix (ECM) stiffness
are hallmarks of vascular aging. Sox9 (SRY-box transcription factor 9) has been implicated …
are hallmarks of vascular aging. Sox9 (SRY-box transcription factor 9) has been implicated …
The inflamm-aging model identifies key risk factors in atherosclerosis
Y He, Y Chen, L Yao, J Wang, X Sha, Y Wang - Frontiers in Genetics, 2022 - frontiersin.org
Background: Atherosclerosis, one of the main threats to human life and health, is driven by
abnormal inflammation (ie, chronic inflammation or oxidative stress) during accelerated …
abnormal inflammation (ie, chronic inflammation or oxidative stress) during accelerated …
PLOD family: a novel biomarker for prognosis and personalized treatment in soft tissue sarcoma
S Gong, N Schopow, Y Duan, C Wu, S Kallendrusch… - Genes, 2022 - mdpi.com
Despite various treatment attempts, the heterogenous group of soft tissue sarcomata (STS)
with more than 100 subtypes still shows poor outcomes. Therefore, effective biomarkers for …
with more than 100 subtypes still shows poor outcomes. Therefore, effective biomarkers for …
[HTML][HTML] PLODs: Novel prognostic biomarkers and potential immunotherapy targets for head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) comprise a group of malignant tumors
arising from the squamous epithelium of the oral cavity, pharynx, and larynx. HNSCC is the …
arising from the squamous epithelium of the oral cavity, pharynx, and larynx. HNSCC is the …
Identification and Validation of Diagnostic Model Based on Angiogenesis-and Epithelial Mesenchymal Transition-Related Genes in Myocardial Infarction
Z Li, S Wang, X Yin, D Tao, X Wang… - International Journal of …, 2024 - Taylor & Francis
Background Myocardial infarction (MI) is a chronic cardiovascular disease. This study aims
to discern potentially angiogenesis-and epithelial mesenchymal transition (EMT)-related …
to discern potentially angiogenesis-and epithelial mesenchymal transition (EMT)-related …
Comparative genomic and biochemical analyses identify a collagen galactosylhydroxylysyl glucosyltransferase from Acanthamoeba polyphaga mimivirus
W Wu, JS Kim, AO Bailey, WK Russell, SJ Richards… - Scientific reports, 2022 - nature.com
Humans and Acanthamoeba polyphaga mimivirus share numerous homologous genes,
including collagens and collagen-modifying enzymes. To explore this homology, we …
including collagens and collagen-modifying enzymes. To explore this homology, we …
基于生物信息学对骨关节炎Hub 基因的筛选与验证
吴素雯， 陈政， 蒋元康， 陈雷雷 - 中国组织工程研究, 2023 - cjter.com
基于生物信息学对骨关节炎Hub 基因的筛选与验证 Page 1 Chinese Journal of Tissue
Engineering Research|Vol 27|No.28|October 2023|4525 中国组织工程研究 Chinese Journal of …
Engineering Research|Vol 27|No.28|October 2023|4525 中国组织工程研究 Chinese Journal of …