As the whole world is epidemically aging, the burden of periodontitis and tooth loss is
becoming a major health concern. Growing meta-epidemiological data implicate chronic …

Abstract Purpose of Review The purpose of this article is to review the current understanding
of inflammatory processes on bone, including direct impacts of inflammatory factors on bone …

Purpose Emerging evidence has indicated that oxidative stress (OS) contributes to
periodontitis. Periodontal ligament cells (PDLCs) are important for the regeneration of …

The senescence-associated secretory phenotype (SASP), which accumulates over the
course of normal aging and in age-related diseases, is a crucial driver of chronic …

Ageing constitutes the biggest risk factor for poor health and adversely affects the integrity
and function of all the cells, tissues, and organs in the human body. Vascular ageing …

As the aging population grows, chronic age-related bone degenerative diseases become
more prevalent and severe. One such disease, periodontitis (PD), rises to 70.1% prevalence …

Accelerated cellular senescence may be a crucial process for periodontitis progression
because it integrates the damaging effects of major periodontitis risk factors. Cellular …

Simple Summary Oral health is increasingly recognized as an important part of overall
health. Tooth loss is a contributor to overall musculoskeletal frailty and is closely associated …

Osteocytes are specialized bone cells that orchestrate skeletal remodeling. Senescent
osteocytes are characterized by an activation of cyclin-dependent kinase inhibitor p16Ink4a …

Bone is a complex organ serving roles in skeletal support and movement, and is a source of
blood cells including adaptive and innate immune cells. Structural and functional integrity is …