Two-pore domain potassium (K2P) channels stabilize the resting membrane potential of
both excitable and nonexcitable cells and, as such, are important regulators of cell activity …

Leak currents, defined as voltage and time independent flows of ions across cell
membranes, are central to cellular electrical excitability control. The K 2P (KCNK) potassium …

Tandem pore domain (K2P) potassium channels modulate resting membrane potentials and
shape cellular excitability. For the mechanosensitive subfamily of K2Ps, the composition of …

Potassium channels are presumed to have two allosterically coupled gates, the activation
gate and the selectivity filter gate, that control channel opening, closing, and inactivation …

Nociceptors, ie sensory neurons tuned to detect noxious stimuli, are found in numerous
phyla of the Animalia kingdom and are often polymodal, responding to a variety of stimuli, eg …

Sleep apnea is a common disorder that represents a global public health burden. KCNK3
encodes TASK-1, a K+ channel implicated in the control of breathing, but its link with sleep …

Potassium (K+) channels are usually predominant in the membranes of vascular smooth
muscle cells (SMCs). These channels play an important role in regulating the membrane …

Cell polarity mechanisms allow the formation of specialized membrane domains with unique
protein compositions, signalling properties, and functional characteristics. By analyzing the …

Mechanosensitive ion channels mediate the neuronal sensation of mechanical signals such
as sound, touch, and pain. Recent studies point to a function of these channel proteins in …

Aims The mode of action by which doxapram acts as a respiratory stimulant in humans is
controversial. Studies in rodent models, have shown that doxapram is a more potent and …