Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …

Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …

The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

Vessel formation and differentiation to a proper hierarchical vasculature requires a
coordinated effort from endothelial and mural cells. Over the last decade Notch was …

Single-cell RNA sequencing (scRNA-seq) provides insights into gene expression
heterogeneities in diverse cell types underlying homeostasis, development and pathological …

The complex landscape of cardiovascular diseases encompasses a wide range of related
pathologies arising from diverse molecular mechanisms and exhibiting heterogeneous …

Background Cardiac fibroblast activation protein (FAP) has an emerging role in heart failure
(HF). A paradoxical reduction in its levels in pathological conditions associated with acute …

Single-cell technology has allowed researchers to probe tissue complexity and dynamics at
unprecedented depth in health and disease. However, the generation of high-dimensionality …

Cardiovascular diseases are the leading cause of death worldwide, with heart failure being
a complex condition that affects millions of individuals. Single-nucleus RNA sequencing has …