Hydroxymethylation and its potential implication in DNA repair system: a review and future perspectives

A Shukla, M Sehgal, TR Singh - Gene, 2015 - Elsevier
Abstract The 5-hydroxymethylcytosine (5-hmC) is known to exist as a predictive indicator for
a variety of cancers, neurological abnormalities and other perilous diseases. The precursor …

An integrative-omics approach to identify functional sub-networks in human colorectal cancer

RK Nibbe, M Koyutürk, MR Chance - PLoS computational biology, 2010 - journals.plos.org
Emerging evidence indicates that gene products implicated in human cancers often cluster
together in “hot spots” in protein-protein interaction (PPI) networks. Additionally, small sub …

Analysis of differential expression proteins reveals the key pathway in response to heat stress in Alicyclobacillus acidoterrestris DSM 3922T

X Feng, C He, L Jiao, X Liang, R Zhao, Y Guo - Food microbiology, 2019 - Elsevier
For the purpose of investigating the heat resistance mechanism of Alicyclobacillus
acidoterrestris, label-free quantification was used to reveal some cellular changes in A …

Computational studies on Alzheimer's disease associated pathways and regulatory patterns using microarray gene expression and network data: Revealed …

PP Panigrahi, TR Singh - Journal of theoretical biology, 2013 - Elsevier
Abstract Alzheimer's disease (AD), which is one of the most common age-associated
neurodegenerative disorders, affects millions of people worldwide. Due to its polygenic …

[PDF][PDF] Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome

H Wu, H Zeng, R Lam, W Tempel… - … Section F: Structural …, 2015 - journals.iucr.org
Mismatch repair prevents the accumulation of erroneous insertions/deletions and non-
Watson–Crick base pairs in the genome. Pathogenic mutations in the MLH1 gene are …

An integrative approach for mapping differentially expressed genes and network components using novel parameters to elucidate key regulatory genes in colorectal …

M Sehgal, R Gupta, A Moussa, TR Singh - Plos one, 2015 - journals.plos.org
For examining the intricate biological processes concerned with colorectal cancer (CRC), a
systems biology approach integrating several biological components and other influencing …

DR-GAS: a database of functional genetic variants and their phosphorylation states in human DNA repair systems

M Sehgal, TR Singh - DNA repair, 2014 - Elsevier
We present DR-GAS 1, a unique, consolidated and comprehensive DNA repair genetic
association studies database of human DNA repair system. It presents information on repair …

Systems biology approach for mutational and site-specific structural investigation of DNA repair genes for xeroderma pigmentosum

M Sehgal, TR Singh - Gene, 2014 - Elsevier
Xeroderma pigmentosum (XP) is a rare genetic skin disorder caused due to the extreme
sensitivity for ultraviolet (UV) radiations. On its exposure, DNA acquires damages leading to …

[PDF][PDF] Mitochondrial genomes and frameshift mutations: Hidden stop codons, their functional consequences and disease associations

TR Singh - Int J Genomic Med, 2013 - academia.edu
Reprogramming of mRNA translation by localized alterations in the standard translational
rules is termed as recoding. Frameshifting is one class of recoding and defined as protein …

NMDB: Network Motif Database envisaged and explicated from human disease specific pathways

A Pratap, S Taliyan, TR Singh - Journal of biological systems, 2014 - World Scientific
The study of network motifs for large number of networks can aid us to resolve the functions
of complex biological networks. In biology, network motifs that reappear within a network …