Maternal obesity and programming of metabolic syndrome in the offspring: searching for mechanisms in the adipocyte progenitor pool

TB Scheidl, AL Brightwell, SH Easson, JA Thompson - BMC medicine, 2023 - Springer
Background It is now understood that it is the quality rather than the absolute amount of
adipose tissue that confers risk for obesity-associated disease. Adipose-derived stem cells …

The adipose tissue at the crosstalk between EDCs and cancer development

E Bokobza, C Hinault, V Tiroille, S Clavel… - Frontiers in …, 2021 - frontiersin.org
Obesity is a major public health concern at the origin of many pathologies, including
cancers. Among them, the incidence of gastro-intestinal tract cancers is significantly …

ITGB2 as a prognostic indicator and a predictive marker for immunotherapy in gliomas

H Xu, A Zhang, X Han, Y Li, Z Zhang, L Song… - Cancer Immunology …, 2022 - Springer
Purpose Glioma is the most common primary tumor in the brain, accounting for 81% of
intracranial malignancies. Nowadays, cancer immunotherapy has become a novel and …

Characterization of tumor microenvironment in glioblastoma multiforme identifies ITGB2 as a key immune and stromal related regulator in glial cell types

AVSS Krishna, A Ramu, S Hariharan, S Sinha… - Computers in Biology …, 2023 - Elsevier
Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor characterized by
inter and intra-tumor heterogeneity and complex tumor microenvironment. To uncover the …

Preclinical and clinical applications of metabolomics and proteomics in glioblastoma research

M Ahmed, AM Semreen, W El-Huneidi… - International Journal of …, 2022 - mdpi.com
Glioblastoma (GB) is a primary malignancy of the central nervous system that is classified by
the WHO as a grade IV astrocytoma. Despite decades of research, several aspects about the …

NAMPT, GRN, and SERPINE1 signature as predictor of disease progression and survival in gliomas

M Vachher, K Arora, A Burman… - Journal of cellular …, 2020 - Wiley Online Library
Adipose tissue is an important source of adipokines involved in anti‐and pro‐inflammatory
effects. Their involvement in certain cancers such as breast and colon cancer is known but in …

Putting proteomics into immunotherapy for glioblastoma

L Chen, D Qin, X Guo, Q Wang, J Li - Frontiers in Immunology, 2021 - frontiersin.org
In glioblastoma, the most aggressive brain cancer, a complex microenvironment of
heterogeneity and immunosuppression, are considerable hurdles to classify the subtypes …

The labyrinthine landscape of APP processing: state of the art and possible novel soluble APP-related molecular players in traumatic brain injury and …

M Masi, F Biundo, A Fiou, M Racchi, A Pascale… - International Journal of …, 2023 - mdpi.com
Amyloid Precursor Protein (APP) and its cleavage processes have been widely investigated
in the past, in particular in the context of Alzheimer's Disease (AD). Evidence of an increased …

Coordinated reprogramming of renal cancer transcriptome, metabolome and secretome associates with immune tumor infiltration

P Poplawski, S Alseekh, U Jankowska… - Cancer Cell …, 2023 - Springer
Background Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal
cancer. The molecules (proteins, metabolites) secreted by tumors affect their extracellular …

Associations of general and abdominal obesity with the risk of glioma development

S Ahn, K Han, JE Lee, SS Jeun, YM Park, SH Yang - Cancers, 2021 - mdpi.com
Simple Summary While obesity is a well-known risk factor for the development of various
types of cancer, conflicting results have been reported concerning the relationship between …