Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some
patients, lung infection leads to the activation of alveolar macrophages and lung epithelial …

Plasma kallikrein (PK) is a serine protease generated from plasma prekallikrein, an
abundant circulating zymogen expressed by the Klkb1 gene. The physiological actions of …

Caloric restriction (CR) increases the preservation of the ovarian primordial follicular
reserve, which can potentially delay menopause. Rapamycin also increases preservation on …

Background The associations between obesity, hypertension and diabetes are well
established, and the renin-angiotensin system (RAS) may provide a link among them. The …

Background Physical exercise induces positive alterations in gene expression involved in
the metabolism of obesity. Maternal exercise provokes adaptations soon after birth in the …

Introduction: Kinins are main active mediators of the kallikrein–kinin system (KKS) via
bradykinin type 1 inducible (B1R) and type 2 constitutive (B2R) receptors. B2R mediates …

The oligopeptidase neurolysin (EC 3.4. 24.16; Nln) was first identified in rat brain synaptic
membranes and shown to ubiquitously participate in the catabolism of bioactive peptides …

The kallikrein–kinin system is a versatile regulatory network implicated in various biological
processes encompassing inflammation, nociception, blood pressure control, and central …

Hemorrhagic transformation (HT) is a major complication of ischemic stroke and further
deteriorates neurological outcomes. Bradykinin 1 receptor (B1R) has been proven to …

Metabolic syndrome is a cluster of metabolic risk factors such as obesity, diabetes and
cardiovascular diseases. Mitochondria is the main site of ATP production and its dysfunction …