Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …

The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …

Corticotropin-releasing hormone (CRH) plays a central role in the regulation of the
hypothalamic-pituitary-adrenal (HPA)-axis, ie, the final common pathway in the stress …

We recently demonstrated that stress-induced cognitive deficits in rats do not correlate with
hippocampal neuronal loss. Working on the premise that subtle structural changes may …

Research on the detrimental effects of stress in the brain has mainly focused on the
hippocampus. Because prefrontal cortex (PFC) dysfunction characterizes many stress …

Adult hippocampal neurogenesis, a once unorthodox concept, has changed into one of the
most rapidly growing fields in neuroscience. The present report results from the ECNP …

Repeated stress is an important risk factor for the development of depression. However, the
mechanism by which stress influences depression is largely unknown, in part due to the fact …

Abstract Analysis of post-mortem tissue from patients with affective disorders has revealed a
decreased number of glial cells in several brain areas. Here, we examined whether long …

A rat model of depression has been recently developed by exogenous corticosterone
administration. In this study, we further determined whether corticosterone administration …

Adult neurogenesis in the dentate gyrus of the hippocampus is altered with stress exposure
and has been implicated in depression. High levels of corticosterone (CORT) suppress …