Targeting signaling pathways in prostate cancer: mechanisms and clinical trials

Y He, W Xu, YT Xiao, H Huang, D Gu… - Signal transduction and …, 2022 - nature.com
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Dietary factors and prostate cancer development, progression, and reduction

M Oczkowski, K Dziendzikowska… - Nutrients, 2021 - mdpi.com
Due to the constantly increasing number of cases, prostate cancer has become one of the
most important health problems of modern societies. This review presents the current …

225Ac-PSMA-617 in chemotherapy-naive patients with advanced prostate cancer: a pilot study

M Sathekge, F Bruchertseifer, O Knoesen… - European journal of …, 2019 - Springer
Background A remarkable therapeutic efficacy has been demonstrated with 225 Ac-prostate-
specific membrane antigen (PSMA)-617 in heavily pre-treated metastatic castration-resistant …

Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling …

G Shan, J Gu, D Zhou, L Li, W Cheng, Y Wang… - … & Molecular Medicine, 2020 - nature.com
Therapeutic failure in prostate cancer (PC) is believed to result from its unusually invasive
and metastatic nature. Cancer-associated fibroblasts (CAFs) are essential in the tumor …

Epigenetic modifications in prostate cancer

M Sugiura, H Sato, M Kanesaka… - … Journal of Urology, 2021 - Wiley Online Library
Prostate cancer is a major cause of cancer‐related deaths among men worldwide. In
addition to genomic alterations, epigenetic alterations accumulated in prostate cancer have …

Histone methyltransferase DOT1L as a promising epigenetic target for treatment of solid tumors

E Alexandrova, A Salvati, G Pecoraro, J Lamberti… - Frontiers in …, 2022 - frontiersin.org
The histone lysine methyltransferase DOT1L (DOT1-like histone lysine methyltransferase) is
responsible for the epigenetic regulation of gene expression through specific methylation of …

DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells

C Pistore, E Giannoni, T Colangelo, F Rizzo… - Oncogene, 2017 - nature.com
Widespread genome hypo-methylation and promoter hyper-methylation of epithelium-
specific genes are hallmarks of stable epithelial-to-mesenchymal transition (EMT), which in …

Volatilomics: an emerging and promising avenue for the detection of potential prostate cancer biomarkers

CV Berenguer, F Pereira, JAM Pereira, JS Câmara - Cancers, 2022 - mdpi.com
Simple Summary The lack of highly specific and sensitive biomarkers for the early detection
of prostate cancer (PCa) is a major barrier to its management. Volatilomics emerged as a …

Healthy lifestyle and cancer risk: modifiable risk factors to prevent cancer

P Marino, M Mininni, G Deiana, G Marino, R Divella… - Nutrients, 2024 - mdpi.com
Cancer has become a serious problem worldwide, as it represents the main cause of death,
and its incidence has increased over the years. A potential strategy to counter the growing …

Prostate cancer chemoprevention by natural agents: Clinical evidence and potential implications

G Chhabra, CK Singh, MA Ndiaye, S Fedorowicz… - Cancer letters, 2018 - Elsevier
Prostate cancer (PCa) is the most common non-skin cancer and the second leading cause
of cancer-related deaths in American men. Due to its long latency period, PCa is considered …