Demystifying functional role of cocaine-and amphetamine-related transcript (CART) peptide in control of energy homeostasis: A twenty-five year expedition

A Singh, AM de Araujo, JP Krieger, M Vergara, CK Ip… - Peptides, 2021 - Elsevier
Cocaine-and amphetamine-related transcript (CART) is a neuropeptide first discovered in
the striatum of the rat brain. Later, the genetic sequence and function of CART peptide …

[HTML][HTML] Arcuate Nucleus of the Hypothalamus: Anatomy, Physiology, and Diseases

J Song, SY Choi - Experimental Neurobiology, 2023 - ncbi.nlm.nih.gov
The hypothalamus is part of the diencephalon and has several nuclei, one of which is the
arcuate nucleus. The arcuate nucleus of hypothalamus (ARH) consists of neuroendocrine …

[HTML][HTML] GPR160 is not a receptor of anorexigenic cocaine-and amphetamine-regulated transcript peptide

LC Freitas-Lima, A Pačesová, J Staňurová… - European Journal of …, 2023 - Elsevier
Cocaine and amphetamine-regulated transcript peptide (CARTp) is an anorexigenic
neuropeptide whose receptor is undisclosed. Previously, we reported the specific binding of …

Probing the orphan receptors: tools and directions

L Franchini, C Orlandi - Progress in Molecular Biology and Translational …, 2023 - Elsevier
The endogenous ligands activating a large fraction of the G Protein Coupled Receptor
(GPCR) family members have yet to be identified. These receptors are commonly labeled as …

Peptidergic modulation of motor neuron output via CART signaling at C bouton synapses

PE Eleftheriadis, K Pothakos… - Proceedings of the …, 2023 - National Acad Sciences
The intensity of muscle contraction, and therefore movement vigor, needs to be adaptable to
enable complex motor behaviors. This can be achieved by adjusting the properties of motor …

GPR-160 receptor signaling in the dorsal vagal complex of male rats modulates meal microstructure and CART-mediated hypophagia

MJ Sanchez-Navarro, T Borner, BC Reiner, RC Crist… - Nutrients, 2023 - mdpi.com
The g-protein coupled receptor GPR-160, recently identified as a putative receptor for the
cocaine and amphetamine-regulated transcript (CART) peptide, shows abundant …

Past, present and future of cocaine-and amphetamine-regulated transcript peptide

GLC Yosten, CJ Haddock, CM Harada… - Physiology & …, 2021 - Elsevier
The existence of the peptide encoded by the cocaine-and amphetamine-regulated transcript
(Cartpt) has been recognized since 1981, but it was not until 1995, that the gene encoding …

Orphan peptide and G protein‐coupled receptor signalling in alcohol use disorder

RG Anversa, XJ Maddern, AJ Lawrence… - British Journal of …, 2024 - Wiley Online Library
Neuropeptides and G protein‐coupled receptors (GPCRs) have long been, and continue to
be, one of the most popular target classes for drug discovery in CNS disorders, including …

Overcoming stress, hunger, and pain: cocaine-and amphetamine-regulated transcript peptide's promise

WK Samson, D Salvemini, GLC Yosten - Endocrinology, 2021 - academic.oup.com
Cocaine-and amphetamine-regulated transcript encodes an eponymous peptide, CARTp,
which exerts diverse pharmacologic actions in the central and peripheral nervous systems …

[HTML][HTML] GPR162 is a beta cell CART receptor

A Lindqvist, M Abels, L Shcherbina, M Ngara… - Iscience, 2023 - cell.com
Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells
and neuronal elements. We have previously established insulinotropic actions of CART in …