Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Abstract I (RPM) presented “The Year In G Protein-Coupled Receptor Research” at ENDO
2009. I first described the diversity of ligands and the five families into which the …

The progression of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) marks
a critical step in the evolution of breast cancer. There is some evidence to suggest that …

The adrenal cortex produces dozens of steroids having varying degrees of glucocorticoid,
mineralocorticoid, and androgenic activity. Cortisol, the principal glucocorticoid, and …

G protein-coupled receptors (GPCRs) are regulated by various downstream proteins, of
which the melanocortin receptor accessory protein 1 (MRAP1) is closely involved in the …

Adolescent development is marked by many changes in neuroendocrine function, resulting
in both immediate and long-term influences on an individual's physiology and behavior …

The melanocortin receptor gene family consists of five single-exon members, which are
located on autosomes. Three genes (MC2R, MC4R and MC5R) are syntenic in the human …

Melanocortin receptors have emerged as important targets with a very unusual versatility, as
their widespread distribution on multiple tissues (eg skin, adrenal glands, brain, immune …

Coincidentally, the release of this Research Topic in Frontiers in Endocrinology takes place
25 years after the discovery of the adrenocorticotropic hormone receptor (ACTHR) by …

The neuroendocrine mechanism underlying stress responses in vertebrates is hypothesized
to be highly conserved and evolutionarily ancient. Indeed, elements of this mechanism, from …