The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …

The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …

Epidermal growth factor (EGF) regulates cell proliferation and differentiation by binding to
the EGF receptor (EGFR) extracellular region, comprising domains I–IV, with the resultant …

Recent crystallographic studies have provided significant new insight into how receptor
tyrosine kinases from the EGF receptor or ErbB family are regulated by their growth factor …

We have determined the 2.6 angstrom crystal structure of the entire extracellular region of
human HER3 (ErbB3), a member of the epidermal growth factor receptor (EGFR) family. The …

Every year,∼ 450,000 individuals in the United States die suddenly of cardiac arrhythmia.
We identified a variant of the cardiac sodium channel gene SCN5A that is associated with …

Structural studies have provided important new insights into how ligand binding promotes
homodimerization and activation of the EGF receptor and the other members of the ErbB …

The epidermal growth factor receptor (EGFR) is a member of the erbB tyrosine kinase family
of receptors. For many years it has been believed that receptor activation occurs via a …

Within a multi-celled organism, regulation and organization require that biological signals be
transmitted from one cell to another, across cell membranes. Such is the case with growth …