The Biosynthesis and Applications of Protein Lipidation

W Ding, J Gu, W Xu, J Wu, Y Huang, S Zhang… - Chemical …, 2024 - ACS Publications
Protein lipidation dramatically affects protein structure, localization, and trafficking via
remodeling protein–membrane and protein–protein interactions through hydrophobic lipid …

Analysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer's disease

P Lian, X Cai, X Yang, Z Ma, C Wang, K Liu, Y Wu… - Apoptosis, 2024 - Springer
Necroptosis, a programmed cell death pathway, has been demonstrated to be activated in
Alzheimer's disease (AD). However, the precise role of necroptosis and its correlation with …

Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell …

KF Suazo, V Mishra, S Maity, SA Auger, K Justyna… - Bioorganic …, 2024 - Elsevier
Protein prenylation is one example of a broad class of post-translational modifications where
proteins are covalently linked to various hydrophobic moieties. To globally identify and …

Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1

KF Suazo, J Bělíček, GL Schey, SA Auger… - RSC Chemical …, 2023 - pubs.rsc.org
Protein lipidation is a post-translational modification that confers hydrophobicity on protein
substrates to control their cellular localization, mediate protein trafficking, and regulate …

PCYOX1L 基因调控LPS 诱导的牛子宫内膜上皮细胞的功能研究

冀国尚, 盛辉, 张俊星, 冯雪, 户春丽, 王雅春, 马燕芬… - 中国畜牧兽医, 2024 - chvm.net
[目的] 探究异戊二烯基半胱氨酸氧化酶-1 样蛋白(prenylcysteineoxidase1likeprotein,
PCYOX1L) 对脂多糖(lipopolysaccharide, LPS) 诱导的牛子宫内膜上皮细胞 …

Novel insights into oligodendrocyte biology from developmental myelination studies in autophagy deficient mice and analysis of oligodendrocyte translatome …

MD Forston - 2023 - ir.library.louisville.edu
Loss of myelin causes severe neurological disorders and functional deficits in white matter
injuries (WMI) such as traumatic spinal cord injury (SCI). This dissertation is focused on …

Evolution, structure, and drug-metabolizing activity of mammalian prenylcysteine oxidases

M Barone, L Pizzorni, MW Fraaije, ML Mascotti… - Journal of Biological …, 2024 - jbc.org
Prenylcysteine oxidases (PCYOXs) metabolize prenylated cysteines produced by protein
degradation. They utilize oxygen as a co-substrate to produce free cysteine, an aldehyde …