[HTML][HTML] Pharmaceutical co-crystallization: Regulatory aspects, design, characterization, and applications

AR Thayyil, T Juturu, S Nayak… - Advanced pharmaceutical …, 2020 - ncbi.nlm.nih.gov
Pharmaceutical co-crystals are novel class of pharmaceutical substances, which possess an
apparent probability of advancement of polished physical properties offering stable and …

Co-crystals: a review

S Chaudhari, SA Nikam, N Khatri… - Journal of Drug Delivery …, 2018 - jddtonline.info
In development of new product major constraints are poor aqueous solubility and low oral
bioavailability. Crystallization is one the approach has been used for enhancement of …

Thermal analysis and FTIR spectral curve-fitting investigation of formation mechanism and stability of indomethacin-saccharin cocrystals via solid-state grinding …

GC Zhang, HL Lin, SY Lin - Journal of pharmaceutical and biomedical …, 2012 - Elsevier
The cocrystal formation of indomethacin (IMC) and saccharin (SAC) by mechanical
cogrinding or thermal treatment was investigated. The formation mechanism and stability of …

Cocrystal of ibuprofen–nicotinamide: solid-state characterization and in vivo analgesic activity evaluation

Y Yuliandra, E Zaini, S Syofyan, W Pratiwi… - Scientia …, 2018 - mdpi.com
Ibuprofen is classified as a BCS class II drug which has low solubility and high permeability.
We conducted the formation of the cocrystalline phase of ibuprofen with coformer …

Preparation and evaluation of pharmaceutical co-crystals for solubility enhancement of atorvastatin calcium

A Naqvi, M Ahmad, MU Minhas, KU Khan, F Batool… - Polymer Bulletin, 2020 - Springer
Co-crystallization is one of the methods to enhance the solubility of hydrophobic drugs that
belong to BCS class II. Preparation and characterization of atorvastatin calcium co-crystals …

Preparation and characterization of artesunate-nicotinamide cocrystal by solvent evaporation and slurry method

D Setyawan, R Sari, H Yusuf… - Asian Journal of …, 2013 - repository.unair.ac.id
Objective: The present study aims to prepare and characterize cocrystals of artesunate (AR)-
nicotinamide (NI) in order to improve bioavailability and efficacy of artesunate as an …

Pharmaceutical cocrystal of antibiotic drugs: A comprehensive review

M Bashimam, H El-Zein - Heliyon, 2022 - cell.com
Pharmaceutical cocrystals, which contain at least one active pharmaceutical ingredient
(API), are still an attention-grabbing field for researchers. Two or more discrete molecules …

Multicomponent crystal of mefenamic acid and N-methyl-D-glucamine: crystal structures and dissolution study

E Zaini, L Fitriani, RY Sari, H Rosaini… - Journal of …, 2019 - Elsevier
A novel multicomponent crystal (MC) of mefenamic acid (MA) and N-methyl-d-glucamine
(MG) had been prepared to improve the physicochemical properties of poorly soluble drugs …

Screening and characterization of cocrystal formation of metaxalone with short-chain dicarboxylic acids induced by solvent-assisted grinding approach

HL Lin, TK Wu, SY Lin - Thermochimica Acta, 2014 - Elsevier
A solvent-assisted grinding approach was used to investigate the possible cocrystal
formation between metaxalone and short-chain dicarboxylic acids (HOOCsingle bond (CH …

Using terahertz time-domain spectroscopical technique to monitor cocrystal formation between piracetam and 2, 5-dihydroxybenzoic acid

Y Du, Y Xia, H Zhang, Z Hong - Spectrochimica Acta Part A: Molecular and …, 2013 - Elsevier
Far-infrared vibrational absorption of cocrystal formation between 2, 5-dihydroxybenzoic
acid (2, 5-DHBA) and piracetam compounds under solvent evaporation and grinding …