Oxidative stress is hypothesized to play a role in pancreatic β-cell damage, potentially
contributing to β-cell dysfunction and death in both type 1 and type 2 diabetes. Oxidative …

The purpose of the current study was to investigate the effect of the recently synthesized
mitochondrially-targeted H 2 S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1, 2-dithiol-5yl) …

Aging and lifestyle-related diseases, such as cardiovascular diseases, diabetes, cancer, and
neurodegenerative disorders, are major global health challenges. These conditions are …

Radiation chemists have been routinely using high-dose microsecond-pulsed irradiation for
almost 60 years, involving many thousands of studies, in the technique of “pulse radiolysis” …

Oxidative stress is thought to promote pancreatic β-cell dysfunction and contribute to both
type 1 and type 2 diabetes. Reactive oxygen species (ROS), such as superoxide and …

H2S and H2O2 are two redox regulating molecules that play important roles in many
physiological and pathological processes. While each of them has distinct biosynthetic …

It is now becoming evident that hydrogen peroxide (H 2 O 2), which is constantly produced
by nearly all cells, contributes to bona fide physiological processes. However, little is known …

Delivery of optimal amounts of brain-derived neurotrophic factor (BDNF) to regions of the
brain affected by neurodegenerative diseases is a daunting task. Using natural products …

As a signaling molecule in mammalian cells, hydrogen peroxide (H 2 O 2) determines the
thiol/disulfide oxidation state of several key proteins in the cytosol. Localization is a key …

Many environmental and physiological stresses are chronic. Thus, cells are constantly
exposed to diverse types of genotoxic insults that challenge genome stability, including …