Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …

Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …

Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor
growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 …

As a predominant type II protein arginine methyltransferase, PRMT5 plays critical roles in
various normal cellular processes by catalyzing the mono-and symmetrical dimethylation of …

Although oxaliplatin-based chemotherapy has been effective in the treatment of
hepatocellular carcinoma (HCC), primary or acquired resistance to oxaliplatin remains a …

Animal models refers to the animal experimental objects and related materials that can
simulate human body established in medical research. As the second-largest disease in …

The serine/arginine-rich splicing factors (SRs) belong to the serine arginine-rich protein
family, which plays an extremely important role in the splicing process of precursor RNA …

Major advances in our understanding of cancer pathogenesis and therapy have come from
efforts to catalog genomic alterations in cancer. A growing number of large-scale genomic …

Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly
universally fatal. Targeted therapy and immunotherapy have had limited success in GBM …