[HTML][HTML] Surface active drugs: self-association and interaction with membranes and surfactants. Physicochemical and biological aspects

S Schreier, SVP Malheiros, E de Paula - Biochimica et Biophysica Acta …, 2000 - Elsevier
Many pharmacologically active compounds are of amphiphilic (or hydrophobic) nature. As a
result, they tend to self-associate and to interact with biological membranes. This review …

Encapsulation of drug molecules by cucurbiturils: effects on their chemical properties in aqueous solution

DH Macartney - Israel Journal of Chemistry, 2011 - Wiley Online Library
The effects of the encapsulation of drugs and other molecules of biomedical interest by
cucurbit [n] uril (n= 5–8, 10) host molecules on the chemical properties of the drugs in …

Exploring membrane organization and dynamics by the wavelength-selective fluorescence approach

A Chattopadhyay - Chemistry and physics of lipids, 2003 - Elsevier
Wavelength-selective fluorescence comprises a set of approaches based on the red edge
effect in fluorescence spectroscopy which can be used to directly monitor the environment …

Host–guest complexations of local anaesthetics by cucurbit [7] uril in aqueous solution

IW Wyman, DH Macartney - Organic & biomolecular chemistry, 2010 - pubs.rsc.org
The cucurbit [7] uril (CB [7]) host molecule forms very stable host–guest complexes with the
local anaesthetics procaine (KCB [7]=(3.5±0.7)× 104 dm3 mol− 1), tetracaine (KCB …

Tetracaine-membrane interactions: effects of lipid composition and phase on drug partitioning, location, and ionization

J Zhang, T Hadlock, A Gent, GR Strichartz - Biophysical journal, 2007 - cell.com
Interactions of the local anesthetic tetracaine with unilamellar vesicles made of dimyristoyl or
dipalmitoyl phosphatidylcholine (DMPC or DPPC), the latter without or with cholesterol, were …

Cucurbit [n] uril Host‐Guest Complexes of Acids, Photoacids, and Super Photoacids

DH Macartney - Israel Journal of Chemistry, 2018 - Wiley Online Library
The supramolecular chemistry of host‐guest complexes of cucurbit [n] urils (CB [n]) with
acidic guests in the ground (HG+) and excited states (HG+*) are reviewed. The effects of CB …

[HTML][HTML] Influence of drug loading on the physical stability of phospholipid-stabilised colloidal lipid emulsions

NM Francke, H Bunjes - International Journal of Pharmaceutics: X, 2020 - Elsevier
When poorly water-soluble drugs are formulated in colloidal lipid emulsions, adequate
stability of the emulsion must be ensured. The aim of this work was to investigate different …

Interaction of benzocaine with model membranes

LMA Pinto, DK Yokaichiya, LF Fraceto, E de Paula - Biophysical Chemistry, 2000 - Elsevier
We measured the absorption properties, water solubility and partition coefficients (P)
between n-octanol, egg phosphatidylcholine (EPC) liposomes and erythrocyte ghosts/water …

Drug localization and its effect on the physical stability of poloxamer 188-stabilized colloidal lipid emulsions

NM Francke, H Bunjes - International Journal of Pharmaceutics, 2021 - Elsevier
Colloidal lipid emulsions are a promising formulation option for poorly water-soluble drugs.
Due to their complex composition, they provide different sites for the localization of drugs …

Effect of anions from the Hofmeister series and urea on the binding of the charged and uncharged forms of the local anesthetic tetracaine to zwitterionic micelles

GSS Ferreira, DM Périgo, MJ Politi… - Photochemistry and …, 1996 - Wiley Online Library
It is widely known that ions in the aqueous phase affect the binding of charged solutes to
membranes. Here we report the effect of ions and urea on the interaction of both the charged …