Exercise metabolism and adaptation in skeletal muscle
Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …
Gut microbial metabolites as multi-kingdom intermediates
KA Krautkramer, J Fan, F Bäckhed - Nature Reviews Microbiology, 2021 - nature.com
The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …
metabolites. These metabolites exert their effects within the host as signalling molecules and …
An exercise-inducible metabolite that suppresses feeding and obesity
Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic
diseases,,,–. However, the molecular and cellular mechanisms that mediate the metabolic …
diseases,,,–. However, the molecular and cellular mechanisms that mediate the metabolic …
Exerkines in health, resilience and disease
LS Chow, RE Gerszten, JM Taylor… - Nature Reviews …, 2022 - nature.com
The health benefits of exercise are well-recognized and are observed across multiple organ
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …
systems. These beneficial effects enhance overall resilience, healthspan and longevity. The …
The microbiota-gut-brain axis
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
Tryptophan metabolism in depression: a narrative review with a focus on serotonin and kynurenine pathways
AS Correia, N Vale - International journal of molecular sciences, 2022 - mdpi.com
Depression is a common and serious disorder, characterized by symptoms like anhedonia,
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
Physical activity and sports—real health benefits: a review with insight into the public health of Sweden
C Malm, J Jakobsson, A Isaksson - Sports, 2019 - mdpi.com
Positive effects from sports are achieved primarily through physical activity, but secondary
effects bring health benefits such as psychosocial and personal development and less …
effects bring health benefits such as psychosocial and personal development and less …
Physical activity and muscle–brain crosstalk
BK Pedersen - Nature Reviews Endocrinology, 2019 - nature.com
Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …
burden of disease. Exercise has many beneficial effects on brain health, contributing to …
The kynurenine pathway: a finger in every pie
J Savitz - Molecular psychiatry, 2020 - nature.com
The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …