Glycogen synthase kinase-3β (GSK-3β) is an evolutionarily conserved serine/threonine
kinase, functioning in numerous cellular processes including cell proliferation, DNA repair …

Pancreatic cancer is a highly malignant and incurable disease, characterized by its
aggressive nature and high fatality rate. The most common type is pancreatic ductal …

Pancreatic cancer is an aggressive malignancy with increasing incidence and poor
prognosis due to its late diagnosis and intrinsic chemoresistance. Most pancreatic cancer …

Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with
two broad lineages referred to as classical (pancreatic) and squamous. We find that these …

Mitochondrial dynamics regulated by mitochondrial fusion and fission maintain
mitochondrial functions, whose alterations underline various human diseases. Here, we …

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified
because of its key role in the regulation of glycogen synthesis. However, it is now well …

Ischemia‐reperfusion injury (IRI) results in irreversible metabolic dysfunction and structural
damage to tissues or organs, posing a formidable challenge in the field of organ …

The S100 protein family genes play a crucial role in multiple stages of tumorigenesis and
progression. Most of S100 genes are located at chromosome locus 1q21, which is a region …

Checkpoint blocking antibodies that interfere in the PD-1/PD-L1 axis provide effective
cancer immunotherapy for tumors that are immune inflamed or induced to become “hot”. It …

Background Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase with multiple
roles in tumour growth, cell invasion and metastasis. We have previously established GSK-3 …