Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs)
locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs …

Neurons transmit and receive information at specialized junctions called synapses.
Excitatory synapses form at the junction between a presynaptic axon terminal and a …

A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …

Membrane fusion is a universal feature of eukaryotic protein trafficking and is mediated by
the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family …

Chemical neurotransmission is the major mechanism of neuronal communication.
Neurotransmitters are released from secretory organelles, the synaptic vesicles (SVs) via …

Autophagy is a cellular degradation pathway essential for neuronal health and function.
Autophagosome biogenesis occurs at synapses, is locally regulated, and increases in …

Parkinson's disease (PD) is a progressive neurodegenerative disease that impairs
movement as well as causing multiple other symptoms such as autonomic dysfunction, rapid …

Synaptopathies are a class of neurodevelopmental disorders caused by modification in
genes coding for synaptic proteins. These proteins oversee the process of …

Endocytosis is a process essential to the health and well-being of cell. It is required for the
internalisation and sorting of “cargo”—the macromolecules, proteins, receptors and lipids of …

The nematode Caenorhabditis elegans is a research model organism particularly suited to
the mechanistic understanding of synapse genesis in the nervous system. Armed with …