Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders

J Han, J Zhang, X Zhang, W Luo, L Liu, Y Zhu… - Stem Cell Research & …, 2024 - Springer
Hippo pathway is an evolutionarily conservative key pathway that regulates organ size and
tissue regeneration by regulating cell proliferation, differentiation and apoptosis. Yes …

Lysophosphatidic Acid/Polydopamine-Modified nHA Composite Scaffolds for Enhanced Osteogenesis via Upregulating the Wnt/Beta-Catenin Pathway

J Chen, Y Qian, H Li, W Zuo, W Sun… - ACS Applied Materials …, 2024 - ACS Publications
Guided bone regeneration (GBR) technology has been widely used for the regeneration of
periodontal bone defects. However, the limited mechanical properties and bone …

Involvement of lysophosphatidic acid-LPA1-YAP signaling in healthy and pathological FAPs migration

A Bock-Pereda, M Cruz-Soca, FS Gallardo… - Matrix Biology, 2024 - Elsevier
Skeletal muscle fibrosis is defined as the excessive accumulation of extracellular matrix
(ECM) components and is a hallmark of muscular dystrophies. Fibro-adipogenic progenitors …

LPA-induced expression of CCN2 in muscular fibro/adipogenic progenitors (FAPs): Unraveling cellular communication networks

A Córdova-Casanova, M Cruz-Soca, FS Gallardo… - Matrix Biology, 2024 - Elsevier
Abstract Cellular Communication Network Factor 2, CCN2, is a profibrotic cytokine
implicated in physiological and pathological processes in mammals. The expression of …

The involvement of YAP-TGFβ-SMAD-mediated fibrosis in primary inferior oblique overaction

S Tang, C Wen, T Shen, B Zhu, X Wang, Z Wang… - … et Biophysica Acta (BBA …, 2025 - Elsevier
This study investigates the involvement of fibrosis in primary inferior oblique overaction
(PIOOA), a strabismus characterized by excessive upward eye rotation. First, we identified …

[HTML][HTML] Targeting AQP9 enhanced the anti-TNF therapy response in Crohn's disease by inhibiting LPA-hippo pathway

M Yu, Y Shi, Y Gao, Y Luo, Y Jin, X Liang, Z Tao… - Pharmacological …, 2024 - Elsevier
Although anti-TNF antibodies are extensively used to treat Crohn's disease (CD), a
significant proportion of patients, up to 40%, exhibit an inadequate response to this therapy …