▪ Abstract The core apparatus that regulates circadian rhythm has been extensively studied
over the past five years. A looming question remains, however, regarding how this …

[Frontiers in Bioscience 8, d520-550, May 1, 2003] 520 BIOCHEMICAL REGULATION OF
NON-RAPID-EYE-MOVEMENT SLEEP Ferenc Obal Jr. 1 Page 1 [Frontiers in Bioscience 8 …

Neuroendocrine mechanisms are major determinants of the normal 24-h blood pressure
(BP) pattern. At the central level, integration of the major driving factors of this temporal …

The etiology of primary open-angle glaucoma (POAG) remains the subject of continuing
investigation. Despite the many known risk factors and mechanism of damage, the principal …

Cerebral stroke, traumatic brain injury, and hypoxic ischemic encephalopathy are among the
most frequently occurring brain injuries. A complex pathogenesis, characterized by a …

During wakefulness, increases in the partial pressure of arterial CO2 result in marked rises
in cortical blood flow. However, during stage III–IV, non-rapid eye movement (NREM) sleep …

Transcranial Doppler (TCD) is used to assess cerebral blood velocity (CBV) and
cerebrovascular reactivity (CVR). Assessments of TCD reproducibility are limited, and few …

The impact of endotoxemia on cerebral endothelium and cerebral blood flow (CBF)
regulation was studied in conscious newborn lambs. Bacterial endotoxin [LPS, 2 μg/kg iv] …

OSA is characterized by the quintessential triad of intermittent apnea, hypoxia, and
hypoxemia due to pharyngeal collapse. This paper highlights the upstream mechanisms that …

Cerebral blood flow measurements during sleep are reviewed and discussed in relation to
the different techniques utilized (Positron Emission Tomography, functional Magnetic …