Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

▪ Abstract Neuronal circuits are shaped by experience during critical periods of early
postnatal life. The ability to control the timing, duration, and closure of these heightened …

The morphological and functional development of the vertebrate nervous system is initially
governed by genetic factors and subsequently refined by neuronal activity. However …

Before the onset of sensory transduction, developing neural circuits spontaneously generate
correlated activity in distinct spatial and temporal patterns. During this period of patterned …

Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are
differently expressed in many regions of the central nervous system (CNS) and peripheral …

The selective elimination of axons, dendrites, axon and dendrite branches, and synapses,
without loss of the parent neurons, occurs during normal development of the nervous system …

Patterns of synaptic connections in the visual system are remarkably precise. These
connections dictate the receptive field properties of individual visual neurons and ultimately …

The neurotransmitter acetylcholine (ACh) exerts its effects on the central nervous system
(CNS) and peripheral nervous system (PNS) through two distinct types of receptors: the …

We have developed a genetic approach to examine the role of spontaneous activity and
synaptic release in the establishment and maintenance of an olfactory sensory map …

Even in the absence of sensory inputs, cortical and thalamic neurons can show structured
patterns of ongoing spontaneous activity, whose origins and functional significance are not …