Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and
misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The …

The motor features of Parkinson's disease (PD) are well known to manifest only when striatal
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor …

The aggregation and prion-like propagation of α-synuclein are involved in the pathogenesis
of Parkinson's disease. However, the underlying mechanisms regulating the assembly and …

Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …

In Parkinson's disease, the progressive neurodegeneration of nigrostriatal dopaminergic
neurons in the substantia nigra pars compacta (SNc) is associated with classic motor …

SARS-CoV2 infection is responsible for a complex clinical syndrome, named Coronavirus
Disease 2019 (COVID-19), whose main consequences are severe pneumonia and acute …

Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …

Parkinson's disease (PD) is characterized by the pathologic aggregation and prion-like
propagation of α-synuclein (α-syn). Emerging evidence shows that fungal infections …

Presynaptic terminals are metabolically active and accrue damage through continuous
vesicle cycling. How synapses locally regulate protein homeostasis is poorly understood …

Parkinson's disease (PD) is considered the most common disorder of synucleinopathy,
which is characterised by intracellular inclusions of aggregated and misfolded α-synuclein …