Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …

Type 2 diabetes mellitus (T2DM) is the most common human endocrine disease and is
characterized by peripheral insulin resistance and pancreatic islet β‐cell failure …

Maintenance of body temperature is achieved partly by modulating lipolysis by a network of
complex regulatory mechanisms. Lipolysis is an integral part of the glycerolipid/free fatty …

Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant
physiological and pharmacological effects. In this review we summarize data from numerous …

Although men with testosterone deficiency are at increased risk for type 2 diabetes (T2D),
previous studies have ignored the role of testosterone and the androgen receptor (AR) in …

Glucose-stimulated insulin secretion (GSIS) is central to normal control of metabolic fuel
homeostasis, and its impairment is a key element of β-cell failure in type 2 diabetes. Glucose …

Palmitate overload induces hepatic cell dysfunction characterized by enhanced apoptosis
and altered citric acid cycle (CAC) metabolism; however, the mechanism of how this occurs …

Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Glucose‐dependent insulinotropic polypeptide (GIP; gastric inhibitory polypeptide) is a 42
amino acid hormone that is produced by enteroendocrine K‐cells and released into the …

Abstract Stimulus-Secretion Coupling (SSC) of pancreatic islet cells comprises electrical
activity. Changes of the membrane potential (V m) are regulated by metabolism-dependent …