Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter
perception and mood and affect numerous cognitive processes. They are generally …

Cortical gain regulation allows neurons to respond adaptively to changing inputs. Neural
gain is modulated by internal and external influences, including attentional and arousal …

Abstract Serotonergic hallucinogens, such as (+)-lysergic acid diethylamide, psilocybin, and
mescaline, are somewhat enigmatic substances. Although these drugs are derived from …

Visual illusions and hallucinations are hallmarks of serotonergic hallucinogen-induced
altered states of consciousness. Although the serotonergic hallucinogen psilocybin activates …

Psychedelics are undergoing a major resurgence of scientific and clinical interest. While
multiple theories and frameworks have been proposed, there is yet no universal agreement …

All neuronal circuits are subject to neuromodulation. Modulatory effects on neuronal
processing and resulting behavioral changes are most commonly reported for higher order …

Genome-wide transcriptional profiling was used to characterize the molecular
underpinnings of neocortical organization in rhesus macaque, including cortical areal …

Psychedelics are quite unique among drugs that impact the central nervous system, as a
single administration of a psychedelic can both rapidly alter subjective experience in …

Ketamine is an N-methyl-d-aspartate antagonist which is increasingly being researched and
used as a treatment for depression. In low doses, it can cause a transitory modification in …

Abstract The mixed serotonin (5-HT) 1A/2A/2B/2C/6/7 receptor agonist psilocybin dose-
dependently induces an altered state of consciousness (ASC) that is characterized by …