New insights into the pathophysiology of dyslipidemia in type 2 diabetes

MR Taskinen, J Borén - Atherosclerosis, 2015 - Elsevier
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality for
patients with type 2 diabetes, despite recent significant advances in management strategies …

Lipid and Carbohydrate Metabolism in Caenorhabditis elegans

JL Watts, M Ristow - Genetics, 2017 - academic.oup.com
Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …

Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway

X Zhu, H Bian, L Wang, X Sun, X Xu, H Yan… - Free Radical Biology …, 2019 - Elsevier
Background Berberine (BBR), a natural compound extracted from Chinese herb, has been
shown to effectively attenuate nonalcoholic fatty liver disease (NAFLD) in clinic. However …

Metabolic dependencies and targets in ovarian cancer

Y Zhang, Y Wang, G Zhao, S Orsulic, D Matei - Pharmacology & …, 2023 - Elsevier
Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

F Benhamed, PD Denechaud… - The Journal of …, 2012 - Am Soc Clin Investig
Nonalcoholic fatty liver disease (NAFLD) is associated with all features of the metabolic
syndrome. Although deposition of excess triglycerides within liver cells, a hallmark of …

Constraints and potentials for the nutritional modulation of the fatty acid composition of ruminant meat

RJB Bessa, SP Alves… - European Journal of Lipid …, 2015 - Wiley Online Library
The meat from ruminants can be a valuable dietary source of rumenic acid (c9, t11‐CLA)
and of n‐3 long chain polyunsaturated fatty acids (n‐3 LC‐PUFA). Nevertheless, commonly …

Role of oleic acid in the gut-liver axis: from diet to the regulation of its synthesis via stearoyl-CoA desaturase 1 (SCD1)

E Piccinin, M Cariello, S De Santis, S Ducheix… - Nutrients, 2019 - mdpi.com
The consumption of an olive oil rich diet has been associated with the diminished incidence
of cardiovascular disease and cancer. Several studies have attributed these beneficial …

Stearoyl-CoA desaturase: rogue or innocent bystander?

L Hodson, BA Fielding - Progress in lipid research, 2013 - Elsevier
Different lipid fractions in humans have characteristic fatty acid profiles and these are
maintained partly through diet and to a lesser extent through endogenous synthesis. The …

[HTML][HTML] Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells

DP Bagchi, A Nishii, Z Li, JB DelProposto, CA Corsa… - Molecular …, 2020 - Elsevier
Abstract Objective Canonical Wnt/β-catenin signaling is a well-studied endogenous
regulator of mesenchymal cell fate determination, promoting osteoblastogenesis and …

Lipidomics reveals associations of phospholipids with obesity and insulin resistance in young adults

S Rauschert, O Uhl, B Koletzko… - The Journal of …, 2016 - academic.oup.com
Context: Obesity and related diseases have become a global public health burden.
Identifying biomarkers will lead to a better understanding of the underlying mechanisms …