HIV and the macrophage: from cell reservoirs to drug delivery to viral eradication
J Herskovitz, HE Gendelman - Journal of Neuroimmune Pharmacology, 2019 - Springer
Macrophages serve as host cells, inflammatory disease drivers and drug runners for human
immunodeficiency virus infection and treatments. Low-level viral persistence continues in …
immunodeficiency virus infection and treatments. Low-level viral persistence continues in …
Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)
J Salemi, DF Obregon, A Cobb, S Reed… - Molecular …, 2011 - Springer
Microglial dysfunction is associated with the pathogenesis and progression of a number of
neurodegenerative disorders including HIV associated dementia (HAD). HIV promotion of …
neurodegenerative disorders including HIV associated dementia (HAD). HIV promotion of …
Chronic intrahippocampal infusion of HIV-1 neurotoxic proteins: a novel mouse model of HIV-1 associated inflammation and neural stem cell dysfunction
JD Hill, V Zuluaga-Ramirez, S Gajghate… - Journal of NeuroImmune …, 2019 - Springer
HIV-1 infection causes chronic neuroinflammation resulting in cognitive decline associated
with diminution of survival of neural stem cells (NSC). In part, this is attributable to production …
with diminution of survival of neural stem cells (NSC). In part, this is attributable to production …
Towards Therapeutic Applications of Arthropod Venom K+‐Channel Blockers in CNS Neurologic Diseases Involving Memory Acquisition and Storage
CDC Gati, MR Mortari, EF Schwartz - Journal of toxicology, 2012 - Wiley Online Library
Potassium channels are the most heterogeneous and widely distributed group of ion
channels and play important functions in all cells, in both normal and pathological …
channels and play important functions in all cells, in both normal and pathological …
Soluble factors from IL-1β-stimulated astrocytes activate NR1a/NR2B receptors: implications for HIV-1-induced neurodegeneration
T Jing, L Wu, K Borgmann, S Surendran… - Biochemical and …, 2010 - Elsevier
Astrocytes play an important role in astrocyte–neuron homeostasis. In HIV-1-infected brain,
interleukin 1 beta (IL-1β) activation of astrocytes contributes to neurodegeneration …
interleukin 1 beta (IL-1β) activation of astrocytes contributes to neurodegeneration …
The Role of HIV-1 Proteins in Alzheimer's Disease Pathology
BN Giunta - 2011 - digitalcommons.usf.edu
Prevalence of HIV-associated cognitive impairment is rising, the worst form of which is HIV-
associated dementia (HAD). The disease is fuiled by a chronic innate type pro-inflammatory …
associated dementia (HAD). The disease is fuiled by a chronic innate type pro-inflammatory …